猫抓病患儿的淋巴结组织学和元基因组测序

IF 7.3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL QJM: An International Journal of Medicine Pub Date : 2024-09-26 DOI:10.1093/qjmed/hcae188

Kaili Fan, Yiwu Cheng, Sheng Hao

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引用次数: 0

摘要

一名 4 岁男孩因发烧和淋巴结病就诊。尽管对疑似淋巴结炎进行了抗生素治疗，但病情改善甚微。淋巴结活检发现了肉芽肿，这引起了对猫抓病（CSD）的怀疑。一个月前，这名男孩曾被一只小猫抓伤。组织的元基因组检测证实了CSD的致病菌鸡巴顿氏菌的存在。将分子诊断工具应用于临床实践对于准确及时地诊断传染病非常重要。

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Lymph Node Histology and Metagenomic Sequencing in a child with Cat Scratch Disease.

A 4-year-old boy presented with fever and lymphadenopathy. Despite antibiotic treatment for suspected lymphadenitis, there was minimal improvement. A lymph node biopsy revealed granulomas, raising suspicion of cat scratch disease (CSD). The boy had been scratched by a kitten a month prior. Metagenomic testing of the tissue confirmed the presence of Bartonella henselae, the causative agent of CSD. It is important to incorporate molecular diagnostic tools into clinical practice for precise and timely diagnosis of infectious diseases.

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来源期刊

QJM: An International Journal of Medicine 医学-医学：内科

CiteScore

6.90

自引率

5.30%

发文量

263

审稿时长

4-8 weeks

期刊介绍： QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles. Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence. In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.