{"title":"发育性语言障碍--遗传率以及与其他影响语言障碍的遗传相关性。","authors":"","doi":"10.1016/j.psychres.2024.116212","DOIUrl":null,"url":null,"abstract":"<div><div>Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Developmental language disorder – heritability and genetic correlations with other disorders affecting language\",\"authors\":\"\",\"doi\":\"10.1016/j.psychres.2024.116212\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.</div></div>\",\"PeriodicalId\":20819,\"journal\":{\"name\":\"Psychiatry Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatry Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165178124004979\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165178124004979","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Developmental language disorder – heritability and genetic correlations with other disorders affecting language
Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.
期刊介绍:
Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry.
The scope of the journal encompasses:
Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders.
Diagnostic assessments of psychiatric disorders.
Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases.
Evaluations of pharmacologic and non-pharmacologic psychiatric treatments.
Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders.
Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.