中风的血脑屏障破坏和成像评估。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY Translational Stroke Research Pub Date : 2024-09-25 DOI:10.1007/s12975-024-01300-6

Yuchen Liang, Yueluan Jiang, Jiaxin Liu, Xuewei Li, Xinyue Cheng, Lei Bao, Hongwei Zhou, Zhenni Guo

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引用次数: 0

摘要

血脑屏障（BBB）破坏是缺血性中风的一个重要病理特征。血脑屏障破坏（BBBD）是缺血的结果，也可能加剧脑实质的损伤。因此，保持血脑屏障的完整性对中枢神经系统（CNS）的平衡至关重要。本综述简要概述了 BBB 的结构和功能，以及中风后 BBB 功能受损的机制。此外，我们还回顾了在缺血性脑损伤背景下研究血脑屏障通透性（BBBP）所采用的最新成像技术，目的是从 BBBD 的角度为脑卒中的诊断和治疗提供成像指导。这些知识对于制定脑缺血期间保护血脑屏障的策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Blood-Brain Barrier Disruption and Imaging Assessment in Stroke.

Disruption of the blood-brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood-brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood-brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.

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来源期刊

Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

13.80

自引率

4.30%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.