{"title":"通过合成生物学实现卟啉的可持续生产。","authors":"Fei Yu, Yongjin J Zhou","doi":"10.1016/j.tibtech.2024.09.009","DOIUrl":null,"url":null,"abstract":"<p><p>Porphyrin compounds are versatile heterocyclic molecules with diverse applications. However, their high-level production is limited by strict biosynthetic regulation and low catalytic efficiency of pathway enzymes. This forum article focuses on recent breakthroughs in porphyrin biosynthesis across various species, aiming to promote the sustainable production of porphyrins through synthetic biology.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sustainable production of porphyrins through synthetic biology.\",\"authors\":\"Fei Yu, Yongjin J Zhou\",\"doi\":\"10.1016/j.tibtech.2024.09.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Porphyrin compounds are versatile heterocyclic molecules with diverse applications. However, their high-level production is limited by strict biosynthetic regulation and low catalytic efficiency of pathway enzymes. This forum article focuses on recent breakthroughs in porphyrin biosynthesis across various species, aiming to promote the sustainable production of porphyrins through synthetic biology.</p>\",\"PeriodicalId\":23324,\"journal\":{\"name\":\"Trends in biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tibtech.2024.09.009\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2024.09.009","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Sustainable production of porphyrins through synthetic biology.
Porphyrin compounds are versatile heterocyclic molecules with diverse applications. However, their high-level production is limited by strict biosynthetic regulation and low catalytic efficiency of pathway enzymes. This forum article focuses on recent breakthroughs in porphyrin biosynthesis across various species, aiming to promote the sustainable production of porphyrins through synthetic biology.
期刊介绍：
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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