Andrea Klang, Christof A Bertram, Taryn A Donovan, Linden E Craig, Ingrid Walter, Birgitt Wolfesberger, Brigitte Degasperi, Elisabeth Baszler, Barbara C Rütgen, Sabine E Hammer, Andrea Fuchs-Baumgartinger
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引用次数: 0
摘要
猫嗜酸性硬化性纤维增生症(FESF)是一种胃肠道和其他部位的增生性炎症疾病,在猫科动物中并不常见。这种病因不明的疾病通常表现为进行性肿块病变,与肿瘤过程相似。在本病例系列中,我们介绍了 17 例与体内淋巴瘤相关的 FESF 病例。这种独特淋巴瘤的组织学和免疫组化特征显示,肿瘤淋巴细胞的 CD56 和/或 CD3 免疫阳性,提示其来源于自然杀伤细胞、自然杀伤 T 细胞或 T 细胞。本系列病例首次描述了这种淋巴瘤亚型,并提出了嗜酸性硬化淋巴瘤这一术语。
Feline eosinophilic sclerosing fibroplasia associated with T-/natural killer-cell lymphoma.
Feline eosinophilic sclerosing fibroplasia (FESF) is a proliferative, inflammatory disease of the gastrointestinal tract and other sites, uncommonly diagnosed in the cat. This entity of uncertain etiology typically presents as a progressive mass lesion, mimicking a neoplastic process. In this case series, we present 17 cases of FESF associated with intralesional lymphoma. Histologic and immunohistochemical characterization of this unique lymphoma revealed that the neoplastic lymphocytes were immunopositive for CD56 and/ or CD3, suggesting a natural killer cell, natural killer T-cell, or T-cell origin. This case series represents the first description of this lymphoma subtype, for which the term eosinophilic sclerosing lymphoma is proposed.
期刊介绍:
Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.