Gianluigi Laccetta, Maria Chiara De Nardo, Raffaella Cellitti, Maria Di Chiara, Monica Tagliabracci, Pasquale Parisi, Flavia Gloria, Giuseppe Rizzo, Alberto Spalice, Gianluca Terrin
{"title":"通过头颅超声定量评估白质损伤以检测早产儿肠外营养的影响:一项观察性研究","authors":"Gianluigi Laccetta, Maria Chiara De Nardo, Raffaella Cellitti, Maria Di Chiara, Monica Tagliabracci, Pasquale Parisi, Flavia Gloria, Giuseppe Rizzo, Alberto Spalice, Gianluca Terrin","doi":"10.3390/jimaging10090224","DOIUrl":null,"url":null,"abstract":"<p><p>Nutrition in early life has an impact on white matter (WM) development in preterm-born babies. Quantitative analysis of pixel brightness intensity (PBI) on cranial ultrasound (CUS) scans has shown a great potential in the evaluation of periventricular WM echogenicity in preterm newborns. We aimed to investigate the employment of this technique to objectively verify the effects of parenteral nutrition (PN) on periventricular WM damage in preterm infants. Prospective observational study including newborns with gestational age at birth ≤32 weeks and/or birth weight ≤1500 g who underwent CUS examination at term-equivalent age. The echogenicity of parieto-occipital periventricular WM relative to that of homolateral choroid plexus (RE<sub>CP</sub>) was calculated on parasagittal scans by means of quantitative analysis of PBI. Its relationship with nutrient intake through enteral and parenteral routes in the first postnatal week was evaluated. The study included 42 neonates for analysis. We demonstrated that energy and protein intake administered through the parenteral route positively correlated with both right and left RE<sub>CP</sub> values (parenteral energy intake vs. right RE<sub>CP</sub>: r = 0.413, <i>p</i> = 0.007; parenteral energy intake vs. left RE<sub>CP</sub>: r = 0.422, <i>p</i> = 0.005; parenteral amino acid intake vs. right RE<sub>CP</sub>: r = 0.438, <i>p</i> = 0.004; parenteral amino acid intake vs. left RE<sub>CP</sub>: r = 0.446, <i>p</i> = 0.003). Multivariate linear regression analysis confirmed these findings. Quantitative assessment of PBI could be considered a simple, risk-free, and repeatable method to investigate the effects of PN on WM development in preterm neonates.</p>","PeriodicalId":37035,"journal":{"name":"Journal of Imaging","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433113/pdf/","citationCount":"0","resultStr":"{\"title\":\"Quantitative Evaluation of White Matter Injury by Cranial Ultrasound to Detect the Effects of Parenteral Nutrition in Preterm Babies: An Observational Study.\",\"authors\":\"Gianluigi Laccetta, Maria Chiara De Nardo, Raffaella Cellitti, Maria Di Chiara, Monica Tagliabracci, Pasquale Parisi, Flavia Gloria, Giuseppe Rizzo, Alberto Spalice, Gianluca Terrin\",\"doi\":\"10.3390/jimaging10090224\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Nutrition in early life has an impact on white matter (WM) development in preterm-born babies. Quantitative analysis of pixel brightness intensity (PBI) on cranial ultrasound (CUS) scans has shown a great potential in the evaluation of periventricular WM echogenicity in preterm newborns. We aimed to investigate the employment of this technique to objectively verify the effects of parenteral nutrition (PN) on periventricular WM damage in preterm infants. Prospective observational study including newborns with gestational age at birth ≤32 weeks and/or birth weight ≤1500 g who underwent CUS examination at term-equivalent age. The echogenicity of parieto-occipital periventricular WM relative to that of homolateral choroid plexus (RE<sub>CP</sub>) was calculated on parasagittal scans by means of quantitative analysis of PBI. Its relationship with nutrient intake through enteral and parenteral routes in the first postnatal week was evaluated. The study included 42 neonates for analysis. We demonstrated that energy and protein intake administered through the parenteral route positively correlated with both right and left RE<sub>CP</sub> values (parenteral energy intake vs. right RE<sub>CP</sub>: r = 0.413, <i>p</i> = 0.007; parenteral energy intake vs. left RE<sub>CP</sub>: r = 0.422, <i>p</i> = 0.005; parenteral amino acid intake vs. right RE<sub>CP</sub>: r = 0.438, <i>p</i> = 0.004; parenteral amino acid intake vs. left RE<sub>CP</sub>: r = 0.446, <i>p</i> = 0.003). Multivariate linear regression analysis confirmed these findings. Quantitative assessment of PBI could be considered a simple, risk-free, and repeatable method to investigate the effects of PN on WM development in preterm neonates.</p>\",\"PeriodicalId\":37035,\"journal\":{\"name\":\"Journal of Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433113/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/jimaging10090224\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/jimaging10090224","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY","Score":null,"Total":0}
Quantitative Evaluation of White Matter Injury by Cranial Ultrasound to Detect the Effects of Parenteral Nutrition in Preterm Babies: An Observational Study.
Nutrition in early life has an impact on white matter (WM) development in preterm-born babies. Quantitative analysis of pixel brightness intensity (PBI) on cranial ultrasound (CUS) scans has shown a great potential in the evaluation of periventricular WM echogenicity in preterm newborns. We aimed to investigate the employment of this technique to objectively verify the effects of parenteral nutrition (PN) on periventricular WM damage in preterm infants. Prospective observational study including newborns with gestational age at birth ≤32 weeks and/or birth weight ≤1500 g who underwent CUS examination at term-equivalent age. The echogenicity of parieto-occipital periventricular WM relative to that of homolateral choroid plexus (RECP) was calculated on parasagittal scans by means of quantitative analysis of PBI. Its relationship with nutrient intake through enteral and parenteral routes in the first postnatal week was evaluated. The study included 42 neonates for analysis. We demonstrated that energy and protein intake administered through the parenteral route positively correlated with both right and left RECP values (parenteral energy intake vs. right RECP: r = 0.413, p = 0.007; parenteral energy intake vs. left RECP: r = 0.422, p = 0.005; parenteral amino acid intake vs. right RECP: r = 0.438, p = 0.004; parenteral amino acid intake vs. left RECP: r = 0.446, p = 0.003). Multivariate linear regression analysis confirmed these findings. Quantitative assessment of PBI could be considered a simple, risk-free, and repeatable method to investigate the effects of PN on WM development in preterm neonates.