Yun Wang, Min Dai, Minghui Zheng, Yan Jin, Quan Wen, Bota Cui, Zulun Zhang, Jianguo Zhu, Faming Zhang
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The primary outcomes were the degree of discomfort and grade of bowel distention. The secondary outcomes were diagnostic accuracy rate through MRE, mental stress, and bowel preparation method preference.</p><p><strong>Results: </strong>A total of 95 CD patients were included in the final analysis. Subjects in the tubing group complained of less vomiting during bowel preparation than those in the oral group (<i>p</i> < 0.05). The degree of nausea and bloating during bowel cleaning for MRE was lower in the tubing group than in the oral group (all <i>p</i> < 0.05). The distention grade was higher in the tubing group compared to the oral group in the splenic flexure of the colon and rectosigmoid colon. The tubing group demonstrated a higher overall diagnostic sensitivity in ulcers compared to the oral group (<i>p</i> = 0.048). Additionally, bowel preparation via the mid-gut tube ameliorated mental stress (<i>p</i> = 0.020) and increased bowel preparation preference (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Bowel preparation through the mid-gut tube enhanced the efficacy and compliance for MRE in CD. This study highlighted the concept of physician-patient satisfaction using mid-gut tube for proper bowel preparation for MRE, enteral nutrition and microbial therapy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT03541733, registered 5 May 2018.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241275337"},"PeriodicalIF":3.9000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437563/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bowel preparation after mid-gut tubing enhanced the efficacy and compliance of magnetic resonance enterography in Crohn's disease: a randomized controlled trial.\",\"authors\":\"Yun Wang, Min Dai, Minghui Zheng, Yan Jin, Quan Wen, Bota Cui, Zulun Zhang, Jianguo Zhu, Faming Zhang\",\"doi\":\"10.1177/17562848241275337\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Magnetic resonance enterography (MRE) has become a routine intestinal imaging examination for Crohn's disease (CD). Sufficient bowel preparation is fundamental for MRE.</p><p><strong>Objectives: </strong>To compare the efficacy and compliance of bowel preparation between through a mid-gut tube and oral administration for MRE in CD.</p><p><strong>Design: </strong>This was an open-label, prospective, multicenter, randomized controlled trial.</p><p><strong>Methods: </strong>Eligible patients were randomized at a 1:1 ratio into an oral group (bowel preparation by oral administration) and a tubing group (bowel preparation through a mid-gut tube). Bowel preparation for MRE included bowel cleaning and bowel distention. The primary outcomes were the degree of discomfort and grade of bowel distention. The secondary outcomes were diagnostic accuracy rate through MRE, mental stress, and bowel preparation method preference.</p><p><strong>Results: </strong>A total of 95 CD patients were included in the final analysis. Subjects in the tubing group complained of less vomiting during bowel preparation than those in the oral group (<i>p</i> < 0.05). The degree of nausea and bloating during bowel cleaning for MRE was lower in the tubing group than in the oral group (all <i>p</i> < 0.05). The distention grade was higher in the tubing group compared to the oral group in the splenic flexure of the colon and rectosigmoid colon. The tubing group demonstrated a higher overall diagnostic sensitivity in ulcers compared to the oral group (<i>p</i> = 0.048). Additionally, bowel preparation via the mid-gut tube ameliorated mental stress (<i>p</i> = 0.020) and increased bowel preparation preference (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Bowel preparation through the mid-gut tube enhanced the efficacy and compliance for MRE in CD. 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引用次数: 0
摘要
背景：磁共振肠造影（MRE）已成为克罗恩病（CD）的常规肠道成像检查。充分的肠道准备是 MRE 的基础：比较通过中肠管和口服给药进行肠道准备对克罗恩病 MRE 的疗效和依从性：这是一项开放标签、前瞻性、多中心、随机对照试验：符合条件的患者按 1:1 的比例随机分为口服组（通过口服进行肠道准备）和管道组（通过中肠管进行肠道准备）。MRE 的肠道准备包括肠道清洁和肠道膨胀。主要结果是不适程度和肠胀气等级。次要结果为 MRE 诊断准确率、精神压力和肠道准备方法偏好：共有 95 名 CD 患者被纳入最终分析。与口服组相比，管道组受试者在肠道准备过程中的呕吐症状较轻（p p = 0.048）。此外，通过中肠管进行肠道准备可缓解精神压力（p = 0.020），并增加肠道准备的偏好（p 结论：通过中肠管进行肠道准备可缓解精神压力（p = 0.020），并增加肠道准备的偏好：通过中肠管进行肠道准备提高了 CD MRE 的疗效和依从性。这项研究强调了使用中肠管为 MRE、肠内营养和微生物治疗进行正确的肠道准备时医患满意度的概念：ClinicalTrials.gov，NCT03541733，2018年5月5日注册。
Bowel preparation after mid-gut tubing enhanced the efficacy and compliance of magnetic resonance enterography in Crohn's disease: a randomized controlled trial.
Background: Magnetic resonance enterography (MRE) has become a routine intestinal imaging examination for Crohn's disease (CD). Sufficient bowel preparation is fundamental for MRE.
Objectives: To compare the efficacy and compliance of bowel preparation between through a mid-gut tube and oral administration for MRE in CD.
Design: This was an open-label, prospective, multicenter, randomized controlled trial.
Methods: Eligible patients were randomized at a 1:1 ratio into an oral group (bowel preparation by oral administration) and a tubing group (bowel preparation through a mid-gut tube). Bowel preparation for MRE included bowel cleaning and bowel distention. The primary outcomes were the degree of discomfort and grade of bowel distention. The secondary outcomes were diagnostic accuracy rate through MRE, mental stress, and bowel preparation method preference.
Results: A total of 95 CD patients were included in the final analysis. Subjects in the tubing group complained of less vomiting during bowel preparation than those in the oral group (p < 0.05). The degree of nausea and bloating during bowel cleaning for MRE was lower in the tubing group than in the oral group (all p < 0.05). The distention grade was higher in the tubing group compared to the oral group in the splenic flexure of the colon and rectosigmoid colon. The tubing group demonstrated a higher overall diagnostic sensitivity in ulcers compared to the oral group (p = 0.048). Additionally, bowel preparation via the mid-gut tube ameliorated mental stress (p = 0.020) and increased bowel preparation preference (p < 0.001).
Conclusion: Bowel preparation through the mid-gut tube enhanced the efficacy and compliance for MRE in CD. This study highlighted the concept of physician-patient satisfaction using mid-gut tube for proper bowel preparation for MRE, enteral nutrition and microbial therapy.
Trial registration: ClinicalTrials.gov, NCT03541733, registered 5 May 2018.
期刊介绍：
Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area.
The editors welcome original research articles across all areas of gastroenterology and hepatology.
The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
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