{"title":"食管癌术后放疗患者在护士指导下进行多模式康复治疗的效果:随机对照试验","authors":"","doi":"10.1016/j.ijrobp.2024.07.025","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose/Objective(s)</h3><div>About 40% of patients develop serious complications after esophageal cancer surgery, which affects the quality of life. Symptoms such as fatigue and appetite loss caused by radiotherapy can also negatively impact the quality of life. However, rehabilitation exercises have been proven to significantly improve the quality of life. This study aimed to compare the effects of nurse-led multimodal rehabilitation versus conventional rehabilitation on physical recovery during adjuvant radiotherapy for postoperative esophageal cancer.</div></div><div><h3>Materials/Methods</h3><div>This randomized controlled trial recruited 70 patients who were randomized into the control group (CG, <em>N</em> = 35) and the intervention group (IG, <em>N</em> = 35). The CG received conventional care, and the IG received nurse-led multimodal rehabilitation. The patient’s quality of life, dyspnea index, fatigue, sleep quality, nutrition, anxiety, and depression were recorded before the start of radiotherapy (T0), after completion of radiotherapy (T1), and 6 months (T2) and 12 months (T3) after completion of radiotherapy. Data were analyzed following intention-to-treat principles. Linear mixed models were used to assess the effects of multimodal rehabilitation over time.</div></div><div><h3>Results</h3><div>The IG significantly increased the global health scores compared to the CG at T1 (difference = 26.19; 95% CI = 17.14 to 35.24; <em>P</em> < 0.001), with differences remaining significant at T2 (difference = 21.43; 95% CI = 8.02 to 34.84; <em>P</em> = 0.002) and T3 (difference = 23.34; 95% CI = 7.31 to 39.36; <em>P</em> = 0.005). Compared with the CG, the weight of the IG was significantly higher at T1 (difference = 3.33; 95% CI = 0.89 to 5.77; <em>P</em> = 0.008), and the difference was still significant at T2 (difference = 3.13; 95% CI = 0.26 to 6.00; <em>P</em> = 0.033) and T3 (difference = 3.91; 95% CI = 0.64 to 7.19; <em>P</em> = 0.020). The fatigue score of the IG decreased significantly at T1(difference = -65.74; 95% CI = -90.74 to -40.75; <em>P</em> < 0.001), and the difference remained statistically significant at T2 (difference = -64.86; 95% CI = -96.98 to -32.74; <em>P</em> < 0.001) and T3 (difference = -48.80; 95% CI = -82.61 to -14.99; <em>P</em> = 0.005). The anxiety and depression status of the IG improved significantly at T1 (difference = -3.00; 95% CI = -4.99 to -1.01; <em>P</em> = 0.004) and (difference = -2.43; 95% CI = -4.48 to -0.38; <em>P</em> = 0.021), and the difference remained significant at T2 (difference = -3.63; 95% CI = -6.84 to -0.42; <em>P</em> = 0.027) and (difference = -3.66; 95% CI = -6.80 to -0.51; <em>P</em> = 0.023).</div></div><div><h3>Conclusion</h3><div>Nurse-led multimodal rehabilitation significantly improved the quality of life, sleep quality, nutrition, fatigue, anxiety, and depression status in patients undergoing postoperative radiotherapy for esophageal cancer.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":null,"pages":null},"PeriodicalIF":6.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of Nurse-Led Multimodal Rehabilitation for Patients Undergoing Postoperative Radiotherapy of Esophageal Cancer: A Randomized Controlled Trial\",\"authors\":\"\",\"doi\":\"10.1016/j.ijrobp.2024.07.025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose/Objective(s)</h3><div>About 40% of patients develop serious complications after esophageal cancer surgery, which affects the quality of life. Symptoms such as fatigue and appetite loss caused by radiotherapy can also negatively impact the quality of life. However, rehabilitation exercises have been proven to significantly improve the quality of life. This study aimed to compare the effects of nurse-led multimodal rehabilitation versus conventional rehabilitation on physical recovery during adjuvant radiotherapy for postoperative esophageal cancer.</div></div><div><h3>Materials/Methods</h3><div>This randomized controlled trial recruited 70 patients who were randomized into the control group (CG, <em>N</em> = 35) and the intervention group (IG, <em>N</em> = 35). The CG received conventional care, and the IG received nurse-led multimodal rehabilitation. The patient’s quality of life, dyspnea index, fatigue, sleep quality, nutrition, anxiety, and depression were recorded before the start of radiotherapy (T0), after completion of radiotherapy (T1), and 6 months (T2) and 12 months (T3) after completion of radiotherapy. Data were analyzed following intention-to-treat principles. Linear mixed models were used to assess the effects of multimodal rehabilitation over time.</div></div><div><h3>Results</h3><div>The IG significantly increased the global health scores compared to the CG at T1 (difference = 26.19; 95% CI = 17.14 to 35.24; <em>P</em> < 0.001), with differences remaining significant at T2 (difference = 21.43; 95% CI = 8.02 to 34.84; <em>P</em> = 0.002) and T3 (difference = 23.34; 95% CI = 7.31 to 39.36; <em>P</em> = 0.005). Compared with the CG, the weight of the IG was significantly higher at T1 (difference = 3.33; 95% CI = 0.89 to 5.77; <em>P</em> = 0.008), and the difference was still significant at T2 (difference = 3.13; 95% CI = 0.26 to 6.00; <em>P</em> = 0.033) and T3 (difference = 3.91; 95% CI = 0.64 to 7.19; <em>P</em> = 0.020). The fatigue score of the IG decreased significantly at T1(difference = -65.74; 95% CI = -90.74 to -40.75; <em>P</em> < 0.001), and the difference remained statistically significant at T2 (difference = -64.86; 95% CI = -96.98 to -32.74; <em>P</em> < 0.001) and T3 (difference = -48.80; 95% CI = -82.61 to -14.99; <em>P</em> = 0.005). The anxiety and depression status of the IG improved significantly at T1 (difference = -3.00; 95% CI = -4.99 to -1.01; <em>P</em> = 0.004) and (difference = -2.43; 95% CI = -4.48 to -0.38; <em>P</em> = 0.021), and the difference remained significant at T2 (difference = -3.63; 95% CI = -6.84 to -0.42; <em>P</em> = 0.027) and (difference = -3.66; 95% CI = -6.80 to -0.51; <em>P</em> = 0.023).</div></div><div><h3>Conclusion</h3><div>Nurse-led multimodal rehabilitation significantly improved the quality of life, sleep quality, nutrition, fatigue, anxiety, and depression status in patients undergoing postoperative radiotherapy for esophageal cancer.</div></div>\",\"PeriodicalId\":14215,\"journal\":{\"name\":\"International Journal of Radiation Oncology Biology Physics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Oncology Biology Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0360301624007879\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Oncology Biology Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0360301624007879","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的/目标:约 40% 的患者在食道癌手术后会出现严重并发症,从而影响生活质量。放疗引起的疲劳和食欲不振等症状也会对生活质量产生负面影响。然而,康复锻炼已被证明能显著提高生活质量。本研究旨在比较护士指导的多模式康复训练与传统康复训练对食管癌术后辅助放疗期间身体恢复的影响。材料/方法本随机对照试验招募了 70 名患者,随机分为对照组(CG,35 人)和干预组(IG,35 人)。对照组接受常规治疗,干预组接受护士指导的多模式康复治疗。分别在放疗开始前(T0)、放疗结束后(T1)、放疗结束后 6 个月(T2)和 12 个月(T3)记录患者的生活质量、呼吸困难指数、疲劳、睡眠质量、营养、焦虑和抑郁情况。数据按照意向治疗原则进行分析。结果与CG相比,IG在T1显著提高了总体健康评分(差异=26.19;95% CI=17.14至35.24;P< 0.001),在T2(差异=21.43;95% CI=8.02至34.84;P=0.002)和T3(差异=23.34;95% CI=7.31至39.36;P=0.005)差异仍然显著。与 CG 相比,IG 的体重在 T1 阶段显著增加(差异 = 3.33;95% CI = 0.89 至 5.77;P = 0.008),在 T2 阶段(差异 = 3.13;95% CI = 0.26 至 6.00;P = 0.033)和 T3 阶段(差异 = 3.91;95% CI = 0.64 至 7.19;P = 0.020)差异仍然显著。IG 的疲劳评分在 T1(差异 = -65.74; 95% CI = -90.74 to -40.75; P <0.001)显著下降,在 T2(差异 = -64.86; 95% CI = -96.98 to -32.74; P <0.001)和 T3(差异 = -48.80; 95% CI = -82.61 to -14.99; P = 0.005)差异仍有统计学意义。IG 的焦虑和抑郁状况在 T1(差异 = -3.00;95% CI = -4.99~-1.01;P = 0.004)和(差异 = -2.43;95% CI = -4.48~-0.38;P = 0.021)时有明显改善,在 T2(差异 = -3.63;95% CI = -6.84~-0.42;P = 0.027)和(差异 = -3.66; 95% CI = -6.80 to -0.51; P = 0.023).结论护士主导的多模式康复显著改善了食管癌术后放疗患者的生活质量、睡眠质量、营养、疲劳、焦虑和抑郁状况。
Effectiveness of Nurse-Led Multimodal Rehabilitation for Patients Undergoing Postoperative Radiotherapy of Esophageal Cancer: A Randomized Controlled Trial
Purpose/Objective(s)
About 40% of patients develop serious complications after esophageal cancer surgery, which affects the quality of life. Symptoms such as fatigue and appetite loss caused by radiotherapy can also negatively impact the quality of life. However, rehabilitation exercises have been proven to significantly improve the quality of life. This study aimed to compare the effects of nurse-led multimodal rehabilitation versus conventional rehabilitation on physical recovery during adjuvant radiotherapy for postoperative esophageal cancer.
Materials/Methods
This randomized controlled trial recruited 70 patients who were randomized into the control group (CG, N = 35) and the intervention group (IG, N = 35). The CG received conventional care, and the IG received nurse-led multimodal rehabilitation. The patient’s quality of life, dyspnea index, fatigue, sleep quality, nutrition, anxiety, and depression were recorded before the start of radiotherapy (T0), after completion of radiotherapy (T1), and 6 months (T2) and 12 months (T3) after completion of radiotherapy. Data were analyzed following intention-to-treat principles. Linear mixed models were used to assess the effects of multimodal rehabilitation over time.
Results
The IG significantly increased the global health scores compared to the CG at T1 (difference = 26.19; 95% CI = 17.14 to 35.24; P < 0.001), with differences remaining significant at T2 (difference = 21.43; 95% CI = 8.02 to 34.84; P = 0.002) and T3 (difference = 23.34; 95% CI = 7.31 to 39.36; P = 0.005). Compared with the CG, the weight of the IG was significantly higher at T1 (difference = 3.33; 95% CI = 0.89 to 5.77; P = 0.008), and the difference was still significant at T2 (difference = 3.13; 95% CI = 0.26 to 6.00; P = 0.033) and T3 (difference = 3.91; 95% CI = 0.64 to 7.19; P = 0.020). The fatigue score of the IG decreased significantly at T1(difference = -65.74; 95% CI = -90.74 to -40.75; P < 0.001), and the difference remained statistically significant at T2 (difference = -64.86; 95% CI = -96.98 to -32.74; P < 0.001) and T3 (difference = -48.80; 95% CI = -82.61 to -14.99; P = 0.005). The anxiety and depression status of the IG improved significantly at T1 (difference = -3.00; 95% CI = -4.99 to -1.01; P = 0.004) and (difference = -2.43; 95% CI = -4.48 to -0.38; P = 0.021), and the difference remained significant at T2 (difference = -3.63; 95% CI = -6.84 to -0.42; P = 0.027) and (difference = -3.66; 95% CI = -6.80 to -0.51; P = 0.023).
Conclusion
Nurse-led multimodal rehabilitation significantly improved the quality of life, sleep quality, nutrition, fatigue, anxiety, and depression status in patients undergoing postoperative radiotherapy for esophageal cancer.
期刊介绍:
International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field.
This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.