Longyu Xiao, Yifan Li, Jun Huang, Li Pan, Pan Wu, Yue Weng
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Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates
This paper aims to explore the applications of modified cysteine in biomedicine, addressing the challenges as-sociated with modifying amino acid residues (cysteine). It provides new avenues for the functionalization of bi-omolecules. Mechanistic studies indicate that the reac-tion involves radical reactions, electrophilic substitution, and nucleophilic substitution. Notably, we demonstrat-ed the method's industrial applicability through gram-scale synthesis via electrochemistry.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.