Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L Femino, Ana L Gonzalez, Leandro L Coutinho, Rebecca L Moffat, Donna Butcher, Elijah F Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T C Wong, Stephen K Anderson, Daniel W McVicar, Sharon A Glynn, Timothy R Billiar, Jenny C Chang, Stephen M Hewitt, Stefan Ambs, Stephen J Lockett, David A Wink
{"title":"肿瘤 NOS2 和 COX2 与 CD8+ T 细胞的空间并存促进了转移和癌干细胞的形成，从而导致 ER- 乳腺癌的不良预后。","authors":"Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L Femino, Ana L Gonzalez, Leandro L Coutinho, Rebecca L Moffat, Donna Butcher, Elijah F Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T C Wong, Stephen K Anderson, Daniel W McVicar, Sharon A Glynn, Timothy R Billiar, Jenny C Chang, Stephen M Hewitt, Stefan Ambs, Stephen J Lockett, David A Wink","doi":"10.1158/2767-9764.CRC-24-0235","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497117/pdf/","citationCount":"0","resultStr":"{\"title\":\"Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.\",\"authors\":\"Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L Femino, Ana L Gonzalez, Leandro L Coutinho, Rebecca L Moffat, Donna Butcher, Elijah F Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T C Wong, Stephen K Anderson, Daniel W McVicar, Sharon A Glynn, Timothy R Billiar, Jenny C Chang, Stephen M Hewitt, Stefan Ambs, Stephen J Lockett, David A Wink\",\"doi\":\"10.1158/2767-9764.CRC-24-0235\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Significance: </strong>This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.</p>\",\"PeriodicalId\":72516,\"journal\":{\"name\":\"Cancer research communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497117/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/2767-9764.CRC-24-0235\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Significance: This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.
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