Soo Jeong Kim, Koeun Lee, Hyun Joo Lee, Du-Young Kang, Young Hwan Kim
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Furthermore, the SUV<sub>max</sub>:tumor size ratio is compared with other established PET parameters.</p><p><strong>Methods: </strong>This study included 108 patients with NSCLC who underwent pretreatment <sup>18</sup>F-FDG PET/CT scans and curative lung surgery. The associations between the SUV<sub>max</sub>:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUV<sub>max</sub>:tumor size ratio was also analyzed. In addition, the SUV<sub>max</sub>:tumor size ratio was compared according to postoperative pathologic findings.</p><p><strong>Results: </strong>In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUV<sub>max</sub>:tumor size ratio was associated with SUV<sub>max</sub> and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUV<sub>max</sub>:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUV<sub>max</sub>:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUV<sub>max</sub>:tumor size ratio than those without. The presence of lymph node metastasis and advanced histologic grade were associated with a high SUV<sub>max</sub>:tumor size ratio in patients with ADC.</p><p><strong>Conclusion: </strong>The SUV<sub>max</sub>:tumor size ratio on pretreatment <sup>18</sup>F-FDG PET/CT scans was associated with aggressive tumor behavior and poor outcome in NSCLCs, particularly ADC.</p><p><strong>Clinical significance: </strong>The SUV<sub>max</sub>:tumor size ratio on pretreatment <sup>18</sup>F-FDG PET/CT scans has a prognostic value in patients with NSCLCs, especially ADC.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Maximum standardized uptake value-to-tumor size ratio in fluorodeoxyglucose F18 positron emission tomography/computed tomography: a simple prognostic parameter for non-small cell lung cancer.\",\"authors\":\"Soo Jeong Kim, Koeun Lee, Hyun Joo Lee, Du-Young Kang, Young Hwan Kim\",\"doi\":\"10.4274/dir.2024.242837\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>By correcting the effect of tumor size on metabolic activity, the maximum standardized uptake value-to-tumor size (SUV<sub>max</sub>:tumor size) ratio on fluorodeoxyglucose F18 positron emission tomography (<sup>18</sup>F-FDG PET)/computed tomography (CT) scans can be a prognostic parameter of non-small cell lung cancer (NSCLC). The current study evaluates the prognostic value of SUV<sub>max</sub>:tumor size ratio on pretreatment <sup>18</sup>F-FDG PET/CT scans in patients with NSCLC. Furthermore, the SUV<sub>max</sub>:tumor size ratio is compared with other established PET parameters.</p><p><strong>Methods: </strong>This study included 108 patients with NSCLC who underwent pretreatment <sup>18</sup>F-FDG PET/CT scans and curative lung surgery. The associations between the SUV<sub>max</sub>:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUV<sub>max</sub>:tumor size ratio was also analyzed. In addition, the SUV<sub>max</sub>:tumor size ratio was compared according to postoperative pathologic findings.</p><p><strong>Results: </strong>In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUV<sub>max</sub>:tumor size ratio was associated with SUV<sub>max</sub> and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUV<sub>max</sub>:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUV<sub>max</sub>:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUV<sub>max</sub>:tumor size ratio than those without. 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引用次数: 0
摘要
目的：通过校正肿瘤大小对代谢活性的影响，氟脱氧葡萄糖F18正电子发射断层扫描（18F-FDG PET）/计算机断层扫描（CT）的最大标准化摄取值与肿瘤大小（SUVmax:肿瘤大小）之比可作为非小细胞肺癌（NSCLC）的预后参数。本研究评估了非小细胞肺癌患者治疗前 18F-FDG PET/CT 扫描的 SUVmax 与肿瘤大小比值的预后价值。此外，还将 SUVmax:tumor size ratio 与其他已确立的 PET 参数进行了比较：本研究纳入了 108 例接受治疗前 18F-FDG PET/CT 扫描和治愈性肺手术的 NSCLC 患者。研究调查了SUVmax：肿瘤大小比与其他常规PET参数之间的关系。还分析了根据 SUVmax:tumor size ratio 得出的无复发生存率。此外，还根据术后病理结果比较了SUVmax:肿瘤大小比：108名参与者中，共有72人（66.7%）患有腺癌（ADC）。19名患者（17.6%）在中位 32.3 个月的随访期间复发。SUV max与肿瘤大小的中位比为2.37（ADC为1.23，其他组织学类型为3.90）。SUVmax:tumor size ratio 与 SUVmax 和平均 SUV 以及代谢肿瘤体积和病变糖酵解总量相关。与SUVmax:肿瘤大小比值低于中位数的患者相比，SUVmax:肿瘤大小比值高于中位数的患者复发率较低。有淋巴管侵犯的ADC患者的SUVmax:肿瘤大小比高于没有淋巴管侵犯的患者。淋巴结转移和组织学分级晚期与ADC患者的高SUVmax:肿瘤大小比相关：结论：治疗前 18F-FDG PET/CT 扫描的 SUVmax：肿瘤大小比与侵袭性肿瘤行为和 NSCLC 的不良预后有关，尤其是 ADC：临床意义：治疗前18F-FDG PET/CT扫描的SUVmax:肿瘤大小比对NSCLC患者尤其是ADC患者具有预后价值。
Maximum standardized uptake value-to-tumor size ratio in fluorodeoxyglucose F18 positron emission tomography/computed tomography: a simple prognostic parameter for non-small cell lung cancer.
Purpose: By correcting the effect of tumor size on metabolic activity, the maximum standardized uptake value-to-tumor size (SUVmax:tumor size) ratio on fluorodeoxyglucose F18 positron emission tomography (18F-FDG PET)/computed tomography (CT) scans can be a prognostic parameter of non-small cell lung cancer (NSCLC). The current study evaluates the prognostic value of SUVmax:tumor size ratio on pretreatment 18F-FDG PET/CT scans in patients with NSCLC. Furthermore, the SUVmax:tumor size ratio is compared with other established PET parameters.
Methods: This study included 108 patients with NSCLC who underwent pretreatment 18F-FDG PET/CT scans and curative lung surgery. The associations between the SUVmax:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUVmax:tumor size ratio was also analyzed. In addition, the SUVmax:tumor size ratio was compared according to postoperative pathologic findings.
Results: In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUVmax:tumor size ratio was associated with SUVmax and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUVmax:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUVmax:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUVmax:tumor size ratio than those without. The presence of lymph node metastasis and advanced histologic grade were associated with a high SUVmax:tumor size ratio in patients with ADC.
Conclusion: The SUVmax:tumor size ratio on pretreatment 18F-FDG PET/CT scans was associated with aggressive tumor behavior and poor outcome in NSCLCs, particularly ADC.
Clinical significance: The SUVmax:tumor size ratio on pretreatment 18F-FDG PET/CT scans has a prognostic value in patients with NSCLCs, especially ADC.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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