Daniel Gutierrez-Barragan, Julian S B Ramirez, Stefano Panzeri, Ting Xu, Alessandro Gozzi
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引用次数: 0
摘要
以前曾利用对 fMRI 时间序列进行时间平均分析的方法描述了多个哺乳动物物种的进化相关网络。然而,fMRI 网络活动是高度动态的,并以秒为时间尺度不断演变。静息态fMRI网络活动的动态组织是否在不同哺乳动物物种之间保持一致仍不清楚。通过对fMRI时间序列进行帧聚类,我们发现清醒的雄性猕猴和人类的内在fMRI网络动态具有在4种主要的、神经解剖学上同源的fMRI共激活模式(C-modes)之间反复转换的特点,其中3种模式在雄性啮齿类动物大脑中也有可信的表现。重要的是,在所有物种中,C-模式都表现出与物种无关的动态特征,包括优先出现在fMRI全局信号波动的特定阶段,以及与次低耦合振荡器动力学兼容的状态转换结构。此外,优势 C 模式的出现重建了所有物种的 fMRI 连接组的静态组织,并可预测相应的 fMRI 连接梯度的排序。这些结果揭示了哺乳动物物种中fMRI网络动态组织的一系列物种不变原则,并为在系统发生树上关联fMRI网络发现提供了新的机会。
Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain.
Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic organization of resting-state fMRI network activity is conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that intrinsic fMRI network dynamics in awake male macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the male rodent brain. Importantly, in all species C-modes exhibit species-invariant dynamic features, including preferred occurrence at specific phases of fMRI global signal fluctuations, and a state transition structure compatible with infraslow coupled oscillator dynamics. Moreover, dominant C-mode occurrence reconstitutes the static organization of the fMRI connectome in all species, and is predictive of ranking of corresponding fMRI connectivity gradients. These results reveal a set of species-invariant principles underlying the dynamic organization of fMRI networks in mammalian species, and offer novel opportunities to relate fMRI network findings across the phylogenetic tree.
期刊介绍:
Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.