IL-4诱导基因1：心肌梗死的潜在参与者

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-20 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509337

Rui Shen, Yan Ding, Qian Dong, Yue Wang, Jian Yu, Chengliang Pan, Yifan Cai, Zhiyang Li, Jiangmei Zhang, Kunwu Yu, Qiutang Zeng

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引用次数: 0

摘要

心肌梗塞（MI）是心血管疾病的一种严重后果，对人类健康构成严重威胁。心肌梗塞发生后，不受控制的炎症和过度的心肌细胞死亡是导致心肌梗塞死亡率和并发症的重要原因。蛋白 IL-4-induced gene 1（IL4I1 或 FIG1）是先天性免疫和适应性免疫的天然抑制剂，在 CD4+ T 细胞分化、巨噬细胞极化和铁变态反应抑制中起着至关重要的作用。以往的研究表明，IL4I1 与急性心肌梗死有关。本综述总结了基础研究和临床研究的证据，强调 IL4I1 是一种重要的免疫调节酶，不仅能调节炎症反应，还可能减轻心肌缺血引起的损伤。

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IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction.

Myocardial infarction (MI), a severe outcome of cardiovascular disease, poses a serious threat to human health. Uncontrolled inflammation and excessive cardiomyocyte death, following an infarction event, significantly contribute to both the mortality rate and complications associated with MI. The protein IL-4-induced gene 1 (IL4I1 or FIG1) serves as a natural inhibitor of innate and adaptive immunity, playing a crucial role in CD4+ T cell differentiation, macrophage polarization, and ferroptosis inhibition. Previous studies have linked IL4I1 to acute MI. This review summarizes evidence from both basic and clinical research, highlighting IL4I1 as a critical immunoregulatory enzyme that not only regulates inflammatory responses, but also potentially mitigates MI-induced damage.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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