白芷通过促进成骨细胞分化缓解模拟微重力诱导的骨质流失

IF 4.4 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES npj Microgravity Pub Date : 2024-10-01 DOI:10.1038/s41526-024-00433-0
Xuechao Liang, Shanfeng Jiang, Peihong Su, Chong Yin, Wei Jiang, Junhong Gao, Zhiyong Liu, Yuhang Li, Weisi Wang, Airong Qian, Ye Tian
{"title":"白芷通过促进成骨细胞分化缓解模拟微重力诱导的骨质流失","authors":"Xuechao Liang, Shanfeng Jiang, Peihong Su, Chong Yin, Wei Jiang, Junhong Gao, Zhiyong Liu, Yuhang Li, Weisi Wang, Airong Qian, Ye Tian","doi":"10.1038/s41526-024-00433-0","DOIUrl":null,"url":null,"abstract":"<p><p>Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredients of AR might act on PTGS2 to prevent bone loss. These results elucidate the efficacy of AR in preventing microgravity-induced bone loss and its potential for use in protecting the bone health of astronauts.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445575/pdf/","citationCount":"0","resultStr":"{\"title\":\"Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.\",\"authors\":\"Xuechao Liang, Shanfeng Jiang, Peihong Su, Chong Yin, Wei Jiang, Junhong Gao, Zhiyong Liu, Yuhang Li, Weisi Wang, Airong Qian, Ye Tian\",\"doi\":\"10.1038/s41526-024-00433-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredients of AR might act on PTGS2 to prevent bone loss. These results elucidate the efficacy of AR in preventing microgravity-induced bone loss and its potential for use in protecting the bone health of astronauts.</p>\",\"PeriodicalId\":54263,\"journal\":{\"name\":\"npj Microgravity\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445575/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Microgravity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41526-024-00433-0\",\"RegionNum\":1,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Microgravity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41526-024-00433-0","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

长期太空飞行造成的骨质流失严重影响宇航员的骨骼健康。目前针对失重引起的骨质流失的治疗方法存在许多缺陷。本研究旨在评估白芷(Angelica dahuricae Radix,AR)对模拟微重力诱发骨质流失的预防作用。在此,我们建立了一个后肢卸载(HLU)小鼠模型,并用白芷(2 克/千克)治疗 HLU 小鼠 4 周。结果表明,AR 能明显抑制模拟微重力诱导的骨质流失。此外,还利用UPLC-MS/MS分析了AR中的成分,结果显示AR中共检测到224种化合物,主要包含7类成分。此外,网络药理学预测表明,AR 的有效成分可能会作用于 PTGS2,从而防止骨质流失。这些结果阐明了 AR 在预防微重力诱导的骨质流失方面的功效,以及其在保护宇航员骨骼健康方面的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.

Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredients of AR might act on PTGS2 to prevent bone loss. These results elucidate the efficacy of AR in preventing microgravity-induced bone loss and its potential for use in protecting the bone health of astronauts.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
期刊最新文献
Dependence of cyanobacterium growth and Mars-specific photobioreactor mass on total pressure, pN2 and pCO2. Formaldehyde initiates memory and motor impairments under weightlessness condition. Development and implementation of a simulated microgravity setup for edible cyanobacteria. Space Analogs and Behavioral Health Performance Research review and recommendations checklist from ESA Topical Team. Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1