Douglas F. Stickle , Gabriel J. DiNatale , Ross Molinaro
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引用次数: 0
摘要
背景:糖化白蛋白(GA糖化白蛋白(GA)通常被描述为过去 2-4 周内葡萄糖暴露的反映。我们从 GA 形成的理论模型的角度,通过模拟葡萄糖变化后 %GA 变化的时间过程,研究了 %GA 变化的操作时间间隔的规模:白蛋白(A)的存活概率根据一阶消除法计算,t1/2 为 17 天。单位时间内 A 形成 GA 的概率与葡萄糖(G)和糖化率常数 k 成正比,糖化率常数 k 是根据%GA 对 G 的参考值推导出来的。然后,我们模拟了在先稳态(恒定 G)后 G 发生阶跃变化的条件下%GA 的变化动力学:糖化速率常数 k 为 9.79e-4/d/(mmol/L)。我们模拟了两种情况下 G 在时间 = 0 时的阶跃变化:A. 从 10 mmol/L 到 15 mmol/L(%GA 最终从 19.3% 变为 26.4%);B. 从 15 mmol/L 到 10 mmol/L(%GA 最终从 26.4% 变为 19.3%)。在这两种情况下,30 天后,%GA 在各自起点和最终终点之间的部分转变约为最终完全转变的 80%:基于模型的计算支持将 GA%描述为过去 4-6 周内 G 的反映,比通常所说的 2-4 周更长。
Minimal mathematical model for glycation of albumin
Background
Glycated albumin (GA) is often described as a reflection of glucose exposure over the past 2–4 weeks. We examined the scale of the operative interval for changes in %GA from the perspective of a theoretical model for GA formation, by simulating the time course of changes in %GA after changes in glucose.
Methods
Probability of survival of albumin (A) was according to first-order elimination based on t1/2 of 17 days. Probability of formation of GA from A per unit time was proportional to glucose (G) and a glycation rate constant, k, deduced from reference values for %GA vs. G. We then simulated the kinetics of changes in %GA for conditions in which a prior steady-state (constant G) was followed by a step change in G.
Results
The glycation rate constant k was 9.79e-4/d/(mmol/L). We simulated changes in %GA for two scenarios involving step changes in G at time = 0: A. from 10 mmol/L to 15 mmol/L (%GA ultimately moves from 19.3% to 26.4%); B. from 15 mmol/L to 10 mmol/L (%GA ultimately moves from 26.4% to 19.3%). For both scenarios, the fractional transition of %GA between respective starting points and ultimate endpoints was after 30 days approximately 80% of the ultimate full transition.
Conclusions
Model-based calculations support the description of %GA as a reflection of G over the past 4–6 weeks, longer than the period of 2–4 weeks that is commonly cited.
期刊介绍:
Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.