抗干扰素γ诱导蛋白16抗体:基于多中心队列研究的特发性间质性肺炎新型自身抗原鉴定及其临床特征。

IF 4.5 3区 医学 Q2 IMMUNOLOGY Clinical immunology Pub Date : 2024-09-30 DOI:10.1016/j.clim.2024.110372
Tsuneo Sasai , Ran Nakashima , Tomohiro Handa , Yasuhiko Yamano , Yasuhiro Kondo , Shogo Matsuda , Takuya Kotani , Hiromi Tomioka , Ryo Tachikawa , Keisuke Tomii , Kiminobu Tanizawa , Yasuhiro Nohda , Toshiaki Kogame , Mirei Shirakashi , Ryosuke Hiwa , Hideaki Tsuji , Shuji Akizuki , Hajime Yoshifuji , Tsuneyo Mimori , Kenji Kabashima , Akio Morinobu
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引用次数: 0

摘要

特发性间质性肺炎(IIPs)中可检测到自身抗体,但没有明确的结缔组织病诊断,其临床意义尚不清楚。本研究旨在确定特发性间质性肺炎中的一种新型自身抗体。我们使用 35S 蛋氨酸标记蛋白质免疫沉淀法对 295 例 IIP 患者进行了筛查。通过蛋白质阵列确定了候选自身抗原,并通过免疫沉淀进行了确认。来自 295 名 IIP 患者的六份血清免疫沉淀了常见的四聚体蛋白(100 kDa)。蛋白质阵列确定干扰素γ诱导蛋白16(IFI16)为候选自身抗原。抗IFI16抗体患者接受免疫抑制剂的频率较低。抗IFI16抗体、抗氨基酸tRNA抗体和其他抗体患者的五年生存率分别为50%、69%和63%(P = 0.60),无急性加重率分别为50%、96%和84%(P = 0.15)。抗IFI16是IIPs中的一种新型自身抗体。有这种抗体的患者通常接受的免疫抑制治疗较少,预后可能较差。需要进一步研究以完善患者分层和管理。
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Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study
Autoantibodies are detected in idiopathic interstitial pneumonias (IIPs) without a clear connective tissue disease diagnosis, and their clinical significance is unclear. This study aimed to identify a novel autoantibody in IIPs. We screened 295 IIP patients using a 35S-methionine labeled protein immunoprecipitation assay. Candidate autoantigens were identified via protein array and confirmed by immunoprecipitation. Six sera from 295 IIP patients immunoprecipitated common tetrameric proteins (100 kDa). The protein array identified interferon gamma-inducible protein 16 (IFI16) as the candidate autoantigen. Patients with anti-IFI16 antibodies received immunosuppressants less frequently. Five-year survival rates were 50 %, 69 %, and 63 % (P = 0.60), and acute exacerbation-free rates were 50 %, 96 %, and 84 % (P = 0.15) for patients with anti-IFI16, anti-aminoacyl tRNA antibodies, and others. Anti-IFI16 is a novel autoantibody in IIPs. Patients with this antibody often receive less immunosuppressive therapy and could have a poor prognosis. Further research is needed to refine patient stratification and management.
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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