用孟鲁司特拮抗胱氨酰白三烯受体治疗视力障碍

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Journal of Ocular Pharmacology and Therapeutics Pub Date : 2024-10-02 DOI:10.1089/jop.2024.0111
Amritha T M Seetharaman, Caroline E Owens, Rajashekhar Gangaraju
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引用次数: 0

摘要

孟鲁司特是美国食品和药物管理局批准的一种治疗哮喘和过敏性鼻炎的药物,它能调节白三烯(LT)受体,是一种重要的抗炎药物。最近的研究表明,孟鲁司特针对的 LT 信号通路对纤维化、心血管疾病、癌症、脑血管疾病和免疫防御等疾病具有更广泛的影响。对这一认识的扩展凸显了孟鲁司特在涉及异常应激机制的疾病(包括以炎症、氧化应激、ER 应激和细胞凋亡等为特征的眼部疾病)中重新使用的潜力。本综述深入探讨了孟鲁司特对各种疾病的治疗机制,将其与眼部疾病进行了比较,并研究了临床试验和相关不良反应,以强调通过孟鲁司特拮抗胱氨酰LT受体作为治疗视力障碍的有效疗法的需求尚未得到满足。
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Cysteinyl Leukotriene Receptor Antagonism by Montelukast to Treat Visual Deficits.

Montelukast, a Food and Drug Administration-approved drug for asthma and allergic rhinitis modulates leukotriene (LT) receptors and serves as a critical anti-inflammatory agent. Recent research suggests that the LT signaling pathway targeted by montelukast has broader implications for diseases such as fibrosis, cardiovascular diseases, cancer, cerebrovascular disease, and immune defense. This expanded understanding highlights montelukast's potential for repurposing in conditions involving aberrant stress mechanisms, including ocular diseases marked by inflammation, oxidative stress, ER stress, and apoptosis, among several others. This review delves into montelukast's therapeutic mechanisms across various diseases, draws parallels to ocular conditions, and examines clinical trials and associated adverse effects to underscore the unmet need for cysteinyl LT receptor antagonism by montelukast as an effective therapy for visual deficits.

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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
72
审稿时长
1 months
期刊介绍: Journal of Ocular Pharmacology and Therapeutics is the only peer-reviewed journal that combines the fields of ophthalmology and pharmacology to enable optimal treatment and prevention of ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of therapeutics for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics coverage includes: Glaucoma Cataracts Retinal degeneration Ocular infection, trauma, and toxicology Ocular drug delivery and biotransformation Ocular pharmacotherapy/clinical trials Ocular inflammatory and immune disorders Gene and cell-based therapies Ocular metabolic disorders Ocular ischemia and blood flow Proliferative disorders of the eye Eyes on Drug Discovery - written by Gary D. Novack, PhD, featuring the latest updates on drug and device pipeline developments as well as policy/regulatory changes by the FDA.
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