儿童和青少年胰腺炎的全球、地区和国家负担。

IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY United European Gastroenterology Journal Pub Date : 2024-10-03 DOI:10.1002/ueg2.12672
Pingping Liu, Ying Wang, Zongbiao Tian, Xiaohuan Dong, Zhijuan Li, Yanfeng Chen
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引用次数: 0

摘要

背景:胰腺炎在儿童和青少年中构成了一个日益严重的公共卫生问题,但有关其流行率、发病率、死亡率和残疾调整生命年(DALYs)的全面数据仍然很少。本研究旨在分析过去 30 年间全球、地区和国家的胰腺炎负担趋势:利用全球疾病负担(GBD)2019数据库中1990-2019年的数据,我们评估了胰腺炎的患病率、发病率、死亡率和DALYs,报告了数字、比率、年龄标准化患病率(ASPR)、年龄标准化发病率(ASIR)、年龄标准化死亡率(ASMR)、年龄标准化DALYs比率(ASDR)和年均百分比变化(AAPCs)。利用联合点分析和预测模型,按年龄、性别、地区和社会人口指数(SDI)对趋势进行了分析:全球范围内,胰腺炎患病率和发病率均有所上升(AAPC患病率=0.13,95% CI:0.11-0.16;AAPC发病率=0.30,95% CI:0.28-0.32),而死亡率和残疾调整生命年率则有所下降(AAPC死亡率=-1.30,95% CI:-1.53,-1.07;AAPC残疾调整生命年率=-1.21,95% CI:-1.41,-1.01)。男女两性的趋势相似。5 岁以下儿童和 15-19 岁青少年的死亡率和残疾调整寿命年数较高。低 SDI 地区的 ASIR 增长幅度最大。东欧的 ASIR、ASMR 和 ASDR 较高且呈上升趋势。预测表明,发病率将继续上升,但死亡率和残疾调整寿命年数将下降:结论:全球儿童和青少年胰腺炎发病率激增,特别是在 SDI 较低的地区。这些发现突出表明,受影响地区迫切需要有针对性的干预措施和医疗资源。
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Global, regional, and national burden of pancreatitis in children and adolescents.

Background: Pancreatitis poses a growing public health concern among children and adolescents, yet comprehensive data on its prevalence, incidence, mortality, and disability-adjusted life years (DALYs) remain scarce. This study aims to analyze global, regional, and national trends in pancreatitis burden over the past 3 decades.

Methods: Using data from the Global Burden of Disease (GBD) 2019 database spanning 1990-2019, we assessed pancreatitis prevalence, incidence, mortality, and DALYs, reporting on numbers, rates, age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized DALYs rate (ASDR), and average annual percentage changes (AAPCs). Trends were analyzed by age, sex, region, and socio-demographic index (SDI) using jointpoint analysis and predictive modeling.

Results: Globally, pancreatitis prevalence and incidence rates have increased (AAPC prevalence = 0.13, 95% CI: 0.11-0.16; AAPC incidence = 0.30, 95% CI: 0.28-0.32), while mortality and DALYs rates have decreased (AAPC mortality = -1.30, 95% CI: -1.53, -1.07; AAPC DALYs = -1.21, 95% CI: -1.41, -1.01). Both genders showed similar trends. Children under 5 and adolescents 15-19 had higher mortality and DALYs rates. Low SDI regions experienced the greatest increase in ASIR. Eastern Europe exhibited high and rising ASIR, ASMR, and ASDR. Projections indicate continued rise in prevalence with declining mortality and DALYs.

Conclusion: Pancreatitis burden in children and adolescents has surged globally, especially in lower SDI regions. These findings underscore the urgent need for targeted interventions and healthcare resources in affected areas.

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来源期刊
United European Gastroenterology Journal
United European Gastroenterology Journal GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
10.50
自引率
13.30%
发文量
147
期刊介绍: United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.
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