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引用次数: 0
摘要
综述的目的：本综述重点介绍乳糜泻领域的最新研究成果：流行病学研究不断发现乳糜泻相关疾病，如炎症性关节炎、肠易激综合征和心血管疾病。最近出版的共识指南为乳糜泻患者的长期管理和监测提供了建议。目前有多种针对乳糜泻的药物疗法正在研究中，本文回顾了近期的 I 期和 II 期试验。最后，最近一项针对非乳糜泻麸质过敏症患者的试验表明，这种疾病具有显著的免死效应：乳糜泻的最新进展包括制定了新的临床指南和前景广阔的新疗法。需要继续开展高质量的研究，以改善乳糜泻和非糜烂性肠病患者的治疗效果。
Purpose of review: This review highlights recent research in the field of celiac disease.
Recent findings: Epidemiological studies continue to identify celiac disease-associated diseases such as inflammatory arthritis, irritable bowel syndrome, and cardiovascular disease. Recently published consensus guidelines provide recommendations for the long-term management and monitoring of patients with celiac disease. There are multiple pharmaceutical therapies for celiac disease under investigation, and recent phase I and phase II trials are reviewed here. Finally, a recent trial of patients with nonceliac gluten sensitivity demonstrates a significant nocebo effect in this condition.
Summary: Recent advances in celiac disease include the development of new clinical guidelines as well as promising new therapeutics. Continued high-quality research is needed to improve the outcomes of patients with celiac disease and nonceliac enteropathies.
期刊介绍：
Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.
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