Riel Castro-Zunti , Kaike Li , Aleti Vardhan , Younhee Choi , Gong Yong Jin , Seok-bum Ko
{"title":"RibFractureSys:诊断急性肋骨骨折的瑰宝。","authors":"Riel Castro-Zunti , Kaike Li , Aleti Vardhan , Younhee Choi , Gong Yong Jin , Seok-bum Ko","doi":"10.1016/j.compmedimag.2024.102429","DOIUrl":null,"url":null,"abstract":"<div><div>Rib fracture patients, common in trauma wards, have different mortality rates and comorbidities depending on how many and which ribs are fractured. This knowledge is therefore paramount to make accurate prognoses and prioritize patient care. However, tracking 24 ribs over upwards 200+ frames in a patient’s scan is time-consuming and error-prone for radiologists, especially depending on their experience.</div><div>We propose an automated, modular, three-stage solution to assist radiologists. Using 9 fully annotated patient scans, we trained a multi-class U-Net to segment rib lesions and common anatomical clutter. To recognize rib fractures and mitigate false positives, we fine-tuned a ResNet-based model using 5698 false positives, 2037 acute fractures, 4786 healed fractures, and 14,904 unfractured rib lesions. Using almost 200 patient cases, we developed a highly task-customized multi-object rib lesion tracker to determine which lesions in a frame belong to which of the 12 ribs on either side; bounding box intersection over union- and centroid-based tracking, a line-crossing methodology, and various heuristics were utilized. Our system accepts an axial CT scan and processes, labels, and color-codes the scan.</div><div>Over an internal validation dataset of 1000 acute rib fracture and 1000 control patients, our system, assessed by a 3-year radiologist resident, achieved 96.1% and 97.3% correct fracture classification accuracy for rib fracture and control patients, respectively. However, 18.0% and 20.8% of these patients, respectively, had incorrect rib labeling. Percentages remained consistent across sex and age demographics. Labeling issues include anatomical clutter being mislabeled as ribs and ribs going unlabeled.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"117 ","pages":"Article 102429"},"PeriodicalIF":5.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RibFractureSys: A gem in the face of acute rib fracture diagnoses\",\"authors\":\"Riel Castro-Zunti , Kaike Li , Aleti Vardhan , Younhee Choi , Gong Yong Jin , Seok-bum Ko\",\"doi\":\"10.1016/j.compmedimag.2024.102429\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Rib fracture patients, common in trauma wards, have different mortality rates and comorbidities depending on how many and which ribs are fractured. This knowledge is therefore paramount to make accurate prognoses and prioritize patient care. However, tracking 24 ribs over upwards 200+ frames in a patient’s scan is time-consuming and error-prone for radiologists, especially depending on their experience.</div><div>We propose an automated, modular, three-stage solution to assist radiologists. Using 9 fully annotated patient scans, we trained a multi-class U-Net to segment rib lesions and common anatomical clutter. To recognize rib fractures and mitigate false positives, we fine-tuned a ResNet-based model using 5698 false positives, 2037 acute fractures, 4786 healed fractures, and 14,904 unfractured rib lesions. Using almost 200 patient cases, we developed a highly task-customized multi-object rib lesion tracker to determine which lesions in a frame belong to which of the 12 ribs on either side; bounding box intersection over union- and centroid-based tracking, a line-crossing methodology, and various heuristics were utilized. Our system accepts an axial CT scan and processes, labels, and color-codes the scan.</div><div>Over an internal validation dataset of 1000 acute rib fracture and 1000 control patients, our system, assessed by a 3-year radiologist resident, achieved 96.1% and 97.3% correct fracture classification accuracy for rib fracture and control patients, respectively. However, 18.0% and 20.8% of these patients, respectively, had incorrect rib labeling. Percentages remained consistent across sex and age demographics. Labeling issues include anatomical clutter being mislabeled as ribs and ribs going unlabeled.</div></div>\",\"PeriodicalId\":50631,\"journal\":{\"name\":\"Computerized Medical Imaging and Graphics\",\"volume\":\"117 \",\"pages\":\"Article 102429\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computerized Medical Imaging and Graphics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S089561112400106X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computerized Medical Imaging and Graphics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S089561112400106X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
RibFractureSys: A gem in the face of acute rib fracture diagnoses
Rib fracture patients, common in trauma wards, have different mortality rates and comorbidities depending on how many and which ribs are fractured. This knowledge is therefore paramount to make accurate prognoses and prioritize patient care. However, tracking 24 ribs over upwards 200+ frames in a patient’s scan is time-consuming and error-prone for radiologists, especially depending on their experience.
We propose an automated, modular, three-stage solution to assist radiologists. Using 9 fully annotated patient scans, we trained a multi-class U-Net to segment rib lesions and common anatomical clutter. To recognize rib fractures and mitigate false positives, we fine-tuned a ResNet-based model using 5698 false positives, 2037 acute fractures, 4786 healed fractures, and 14,904 unfractured rib lesions. Using almost 200 patient cases, we developed a highly task-customized multi-object rib lesion tracker to determine which lesions in a frame belong to which of the 12 ribs on either side; bounding box intersection over union- and centroid-based tracking, a line-crossing methodology, and various heuristics were utilized. Our system accepts an axial CT scan and processes, labels, and color-codes the scan.
Over an internal validation dataset of 1000 acute rib fracture and 1000 control patients, our system, assessed by a 3-year radiologist resident, achieved 96.1% and 97.3% correct fracture classification accuracy for rib fracture and control patients, respectively. However, 18.0% and 20.8% of these patients, respectively, had incorrect rib labeling. Percentages remained consistent across sex and age demographics. Labeling issues include anatomical clutter being mislabeled as ribs and ribs going unlabeled.
期刊介绍:
The purpose of the journal Computerized Medical Imaging and Graphics is to act as a source for the exchange of research results concerning algorithmic advances, development, and application of digital imaging in disease detection, diagnosis, intervention, prevention, precision medicine, and population health. Included in the journal will be articles on novel computerized imaging or visualization techniques, including artificial intelligence and machine learning, augmented reality for surgical planning and guidance, big biomedical data visualization, computer-aided diagnosis, computerized-robotic surgery, image-guided therapy, imaging scanning and reconstruction, mobile and tele-imaging, radiomics, and imaging integration and modeling with other information relevant to digital health. The types of biomedical imaging include: magnetic resonance, computed tomography, ultrasound, nuclear medicine, X-ray, microwave, optical and multi-photon microscopy, video and sensory imaging, and the convergence of biomedical images with other non-imaging datasets.