炎症对射血分数保留型心脏代谢性心力衰竭的影响

Edward B Thorp, Mallory Filipp
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引用次数: 0

摘要

最常见的心力衰竭是射血分数保留型心力衰竭(HFpEF)。虽然起源各异,但最常见的 HFpEF 是心脏代谢性表现。肥胖和衰老会促进全身炎症,这似乎与心脏代谢性 HFpEF 的病理生理学密不可分。心脏内免疫细胞的积聚,再加上代谢组的改变,导致了心脏炎症和纤维化。尽管如此,广泛的抗炎治疗并未显示出对患者预后的显著益处。因此,了解 HFpEF 期间与代谢和年龄相关的炎症的细微差别对于采取更有针对性的干预措施至关重要。在此,我们回顾了高频低氧血症(HFpEF)中炎症的临床证据,并总结了我们对免疫代谢炎症的机理认识,同时强调了具有治疗潜力的途径。
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Contributions of Inflammation to Cardiometabolic Heart Failure with Preserved Ejection Fraction.

The most common form of heart failure is heart failure with preserved ejection fraction (HFpEF). While heterogeneous in origin, the most common form of HFpEF is the cardiometabolic manifestation. Obesity and aging promote systemic inflammation that appears integral to cardiometabolic HFpEF pathophysiology. Accumulation of immune cells within the heart, fueled by an altered metabolome, contribute to cardiac inflammation and fibrosis. In spite of this, broad anti-inflammatory therapy has not shown significant benefit in patient outcomes. Thus, understanding of the nuances to metabolic and age-related inflammation during HFpEF is paramount for more targeted interventions. Here, we review clinical evidence of inflammation in the context of HFpEF and summarize our mechanistic understanding of immunometabolic inflammation, highlighting pathways of therapeutic potential along the way.

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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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