[新型体内血小板活化标记--可溶性 CLEC-2]。

Katsue Suzuki-Inoue
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引用次数: 0

摘要

与抗凝剂不同,抗血小板药物没有很好的监测方法,因此没有必要对其进行监测。血小板聚集试验是血小板功能的标准检测方法,通过向比色皿中的血小板添加血小板活化剂来评估血小板聚集情况。因此,它提供的信息是血小板诱导聚集的最大潜力,而不是血小板在体内的实际活化程度。体内血小板活化标记物需要特殊的采血方法,因此并未得到广泛应用,不过有些检测项目属于保险范围。我和我的同事确定了血小板活化受体 C 型凝集素样受体 2(CLEC-2),并发现 CLEC-2 在血小板活化过程中会被裂解和释放。我们建立了血浆可溶性 CLEC-2(sCLEC-2)检测系统,目的是将其用作体内血小板活化的标志物。各种血栓性疾病中都有 sCLEC-2 升高的报道。目前正在进行多中心前瞻性队列研究 CLECSTRO,研究 sCLEC-2 在急性缺血性中风的诊断、分型和预后评估中的作用。
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[The novel in vivo platelet activation marker, soluble CLEC-2].

Unlike for anticoagulants, no good monitoring methods exist for antiplatelet agents, and their monitoring is considered unnecessary. In the platelet aggregation test, which is the standard test for platelet function, aggregation is evaluated by adding a platelet activator to platelets in a cuvette. Therefore, it provides information on the maximum potential of platelets to induce aggregation, but not the actual in vivo degree of platelet activation. In vivo platelet activation markers are not widely used because they require a special blood collection method, although some tests are covered by insurance. My colleagues and I identified the platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) and found that CLEC-2 is cleaved and released during platelet activation. We established a plasma-soluble CLEC-2 (sCLEC-2) assay system with the aim of using it as a marker of in vivo platelet activation. Elevation of sCLEC-2 has been reported in various thrombotic diseases. The multi-center prospective cohort study CLECSTRO is now underway to investigate the usefulness of sCLEC-2 for diagnosis, typing, and prognostic estimation in acute ischemic stroke.

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