[血小板生成素介导的造血干细胞调节]。

Ayako Nakamura-Ishizu
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引用次数: 0

摘要

维持终生造血需要造血干细胞的维持、增殖和分化。促血小板生成素是一种细胞因子,对调节造血干细胞以及血小板生成所需的巨核细胞的分化和成熟至关重要。由于这些特性,血小板生成素激动剂已被用于治疗再生障碍性贫血等骨髓衰竭综合症。通过对血小板生成素基因缺陷小鼠的分析,我和我的同事证明了血小板生成素受体激动剂在造血干细胞维持和分化中的作用机制。这篇综述的重点是血小板生成素信号对造血系统稳态的调控。
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[Thrombopoietin-mediated regulation of hematopoietic stem cells].

Sustaining lifelong hematopoiesis requires maintenance, proliferation, and differentiation of hematopoietic stem cells. Thrombopoietin is a cytokine essential for regulation of hematopoietic stem cells as well as differentiation and maturation of megakaryocytes required for platelet production. Due to these properties, thrombopoietin agonists have been used to treat bone marrow failure syndromes such as aplastic anemia. Through analysis of thrombopoietin gene-deficient mice, my colleagues and I have demonstrated the mechanism of action of thrombopoietin receptor agonists in hematopoietic stem cell maintenance and differentiation. This review focuses on governance of homeostasis in the hematopoietic system by thrombopoietin signaling.

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