中性粒细胞胞外捕获物与心血管疾病：相关性和潜在治疗方法。

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomedicine & Pharmacotherapy Pub Date : 2024-10-01 DOI:10.1016/j.biopha.2024.117476

Yiyue Tang , Yang Jiao , Xiaohua An , Qingxian Tu , Qianfeng Jiang

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引用次数: 0

摘要

心血管疾病（CVD）是全球关注的重大健康问题，在 190 个国家和地区，它是导致残疾调整寿命年数（DALY）的五大原因之一。中性粒细胞是先天性免疫系统的关键角色，它通过释放由 DNA、组蛋白、弹性蛋白酶、髓过氧化物酶和抗菌肽组成的中性粒细胞胞外捕获物（NET）来对抗感染。本文探讨了中性粒细胞胞外捕获物与心血管疾病之间的关系，重点是心力衰竭、肺动脉高压、心房颤动和缺血再灌注损伤等疾病。特别是研究了NET对心房颤动和肺动脉高压的影响，以及髓过氧化物酶（MPO）和中性粒细胞弹性蛋白酶（NE）在这些疾病中的作用。此外，还讨论了针对 NETs 治疗心血管疾病的潜力。

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Neutrophil extracellular traps and cardiovascular disease: Associations and potential therapeutic approaches

Cardiovascular disease (CVD) is a significant global health concern, ranking among the top five causes of disability-adjusted life-years (DALY) in 190 countries and territories. Neutrophils, key players in the innate immune system, combat infections by releasing neutrophil extracellular traps (NETs) composed of DNA, histones, elastase, myeloperoxidase, and antimicrobial peptides. This paper explores the relationship between NETs and cardiovascular diseases, focusing on conditions such as heart failure, pulmonary hypertension, atrial fibrillation, and ischemia-reperfusion injury. Particularly, it delves into the impact of NETs on atrial fibrillation and pulmonary hypertension, as well as the role of myeloperoxidase (MPO) and neutrophil elastase (NE) in these diseases. Furthermore, the potential of targeting NETs for the treatment of cardiovascular diseases is discussed.

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.