PRC2-RNA 相互作用：Jimmy K. Guo、Mario R. Blanco 和 Mitchell Guttman 的观点

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.09.007

Jimmy K. Guo, Mario R. Blanco, Mitchell Guttman

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引用次数: 0

摘要

许多报道的 PRC2-RNA 相互作用已被证明在功能上是可有可无的，从而引发了关于它们是否在体内发生的疑问。在这里，我们阐述了现有直接结合证据的技术问题，并认为目前缺乏 PRC2-RNA 在体内直接结合的生化或功能证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PRC2-RNA interactions: Viewpoint from Jimmy K. Guo, Mario R. Blanco, and Mitchell Guttman

Many reported PRC2-RNA interactions have been shown to be functionally dispensable, raising questions about whether they occur in vivo. Here, we lay out technical issues with existing evidence for direct binding and argue that there is currently a lack of biochemical or functional evidence for direct PRC2-RNA binding in vivo.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.