动态构象:向环形 RNA 的功能和应用迈进

IF 14.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.08.020
Chu-Xiao Liu, Li Yang, Ling-Ling Chen
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引用次数: 0

摘要

环状 RNA 是一组共价封闭的单链转录本,具有独特的生物发生、稳定性和构象,在调节细胞功能方面发挥着不同的作用,在开发基于环状 RNA 的疗法方面也具有巨大潜力。重要的是,由于其环状构象,环状 RNA 会产生不同于线性转录本的分子内碱基配对。在这一视角中,我们回顾了环状 RNA 构象如何影响其周转和作用模式,以及哪些因素可以调节环状 RNA 构象。我们还讨论了了解环状 RNA 构象如何促进对其功能的了解,以及进一步解决其构象问题的剩余技术问题。这些努力最终将为设计基于环状 RNA 的生物医学应用平台提供信息。
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Dynamic conformation: Marching toward circular RNA function and application
Circular RNA is a group of covalently closed, single-stranded transcripts with unique biogenesis, stability, and conformation that play distinct roles in modulating cellular functions and also possess a great potential for developing circular RNA-based therapies. Importantly, due to its circular conformation, circular RNA generates distinct intramolecular base pairing that is different from the linear transcript. In this perspective, we review how circular RNA conformation can affect its turnover and modes of action, as well as what factors can modulate circular RNA conformation. We also discuss how understanding circular RNA conformation can facilitate learning about their functions as well as the remaining technological issues to further address their conformation. These efforts will ultimately inform the design of circular RNA-based platforms for biomedical applications.
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来源期刊
Molecular Cell
Molecular Cell 生物-生化与分子生物学
CiteScore
26.00
自引率
3.80%
发文量
389
审稿时长
1 months
期刊介绍: Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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