黑暗中的火花发现脑肿瘤中的动作电位

IF 48.8 1区医学 Q1 CELL BIOLOGY Cancer Cell Pub Date : 2024-10-03 DOI:10.1016/j.ccell.2024.09.004

Nikolas Andreas Stevens, Nina Drewa, Varun Venkataramani

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引用次数: 0

摘要

胶质瘤表现出明显的分子多样性和不良预后。在本期《癌细胞》（Cancer Cell）杂志上，Curry 等人对人类胶质瘤样本进行了 Patch-seq 分析，发现了具有胶质和神经元特征的混合细胞，它们能在异柠檬酸脱氢酶突变型胶质瘤中产生动作电位。这些发现凸显了神经特征在肿瘤生物学和进展中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spark in the darkness: Discovering action potentials in brain tumors

Gliomas exhibit significant molecular diversity and poor prognosis. In this issue of Cancer Cell, Curry et al. apply Patch-seq on human glioma samples uncovering hybrid cells with glial and neuronal features, capable of firing action potentials in isocitrate dehydrogenase mutant gliomas. These findings highlight the importance of neural features in tumor biology and progression.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.