机械通气断气后,吸气肌训练对 COVID-19 患者肌肉损伤生物标志物的影响。

IF 3.5 3区 医学 Q2 RESPIRATORY SYSTEM Chronic Respiratory Disease Pub Date : 2024-01-01 DOI:10.1177/14799731241289423
Muneeb Iqbal, Kumail Hassan, Edward Bliss, Eliza J Whiteside, Ben Hoffman, Dean E Mills
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引用次数: 0

摘要

背景:COVID-19 患者会出现呼吸肌损伤,导致呼吸功能和功能能力下降,通常需要机械通气,这进一步增加了肌无力的易感性。吸气肌训练(IMT)有助于减轻这种损伤,改善呼吸功能和功能能力。方法:我们研究了 IMT 对 COVID-19 中成功脱离机械通气的恢复期青壮年肌肉损伤生物标志物、呼吸功能和功能能力的影响。参与者被随机分配到 IMT 组(n = 11)或对照组(CON;n = 11)进行为期 4 周的干预。IMT 组每天进行两次 30 次动态吸气,吸气压力为最大吸气口压(PMmax)的 50%,而 CON 组每天进行 60 次吸气,吸气压力为 pMmax 的 10%。在基线、第二周和第四周收集血清,测量肌酸激酶肌型(CKM)、快速骨骼肌肌钙蛋白-I(sTnI)和慢速骨骼肌肌钙蛋白-I。结果显示肌酸激酶和慢肌钙蛋白(sTnI)出现了时间×组别的交互效应,而快肌钙蛋白(sTnI)则没有。与 CON 组相比,IMT 组在 2 周和 4 周时这两项指标均较低。在 1s 强迫呼气量、强迫生命容量、PMmax 和左右手握力方面,观察到了时间×组别的交互效应。与 CON 组相比,IMT 组的交互效应更高。结论为期四周的 IMT 可减少 COVID-19 患者机械通气断奶后肌肉损伤的生物标志物,并增强其呼吸功能和握力。
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The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation.

Background: COVID-19 patients experience respiratory muscle damage, leading to reduced respiratory function and functional capacity often requiring mechanical ventilation which further increases susceptibility to muscle weakness. Inspiratory muscle training (IMT) may help mitigate this damage and improve respiratory function and functional capacity. Methods: We studied the effects of IMT on muscle damage biomarkers, respiratory function, and functional capacity in COVID-19 recovered young adults, successfully weaned from mechanical ventilation. Participants were randomly allocated to either an IMT (n = 11) or control (CON; n = 11) intervention for 4 weeks. The IMT group performed 30 dynamic inspiratory efforts twice daily, at 50% of their maximal inspiratory mouth pressure (PMmax) while the CON group performed 60 inspiratory efforts at 10% of pMmax daily. Serum was collected at baseline, week two, and week four to measure creatine kinase muscle-type (CKM), fast skeletal troponin-I (sTnI) and slow sTnI. Results: Time × group interaction effects were observed for CKM and slow sTnI, but not for fast sTnI. Both were lower at two and 4 weeks for the IMT compared to the CON group, respectively. Time × group interaction effects were observed for forced expiratory volume in 1s, forced vital capacity, PMmax and right- and left-hand grip strength. These were higher for the IMT compared to the CON group. Conclusion: Four weeks of IMT decreased muscle damage biomarkers and increased respiratory function and grip strength in recovered COVID-19 patients after weaning from mechanical ventilation.

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来源期刊
Chronic Respiratory Disease
Chronic Respiratory Disease RESPIRATORY SYSTEM-
CiteScore
5.90
自引率
7.30%
发文量
47
审稿时长
11 weeks
期刊介绍: Chronic Respiratory Disease is a peer-reviewed, open access, scholarly journal, created in response to the rising incidence of chronic respiratory diseases worldwide. It publishes high quality research papers and original articles that have immediate relevance to clinical practice and its multi-disciplinary perspective reflects the nature of modern treatment. The journal provides a high quality, multi-disciplinary focus for the publication of original papers, reviews and commentary in the broad area of chronic respiratory disease, particularly its treatment and management.
期刊最新文献
Quantifying uptake and completion of pulmonary rehabilitation programs in people with chronic obstructive pulmonary disease known to tertiary care. Navigating the COVID-19 pandemic: Experiences and self-management approaches adopted by people with interstitial lung disease. Relationship between dust allergen sensitization and cardiac autonomic function in patients with chronic obstructive pulmonary disease. Respiratory impairments in patients suffering from Fabry disease - A cross-sectional study. Two-year diffusion capacity trajectory in COVID-19 pneumonia survivors.
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