先天性淋巴细胞与传染病。

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Innate Immunity Pub Date : 2024-10-03 DOI:10.1177/17534259241287311
Ting Yuan, Qianhui Zhou, Yuqiu Tian, Yangjing Ou, YunZhu Long, YingZheng Tan
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引用次数: 0

摘要

先天性淋巴细胞(ILCs)是主要的常驻淋巴细胞,由于缺乏适应性抗原受体,它们大多驻留在组织中。这些细胞参与早期抗感染免疫、抗肿瘤免疫、调节组织炎症和维持组织内环境平衡,被称为 "驻扎在人体的第一支军队"。ILCs 广泛分布于肺、结肠、淋巴结、口腔粘膜甚至胚胎组织。相关研究表明,ILCs 在防御各种病原微生物(包括细菌、病毒、真菌和蠕虫)的过程中发挥着早期作用,然后才介入适应性免疫系统。在启动适应性免疫反应之前,ILCs 可针对病原体启动快速的非特异性反应,并可针对特定病原体产生保护性免疫反应,分泌不同的效应因子发挥作用。在本文中,我们总结并讨论了目前已知的 ILCs 参与的传染病,以及 ILC 对防御传染病的贡献。进一步了解 ILCs 在不同传染病中的作用机制将有助于开发早期控制传染病的治疗策略。
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Innate lymphoid cells and infectious diseases.

Innate lymphoid cells (ILCs) are the main resident lymphocytes that mostly reside in tissues owing to the lack of adaptive antigen receptors. These cells are involved in early anti-infective immunity, antitumour immunity, regulation of tissue inflammation, and maintenance of homeostasis in the internal environment of tissues and have been referred to as the "first armies stationed in the human body". ILCs are widely distributed in the lungs, colon, lymph nodes, oral mucosa and even embryonic tissues. Due to the advantage of their distribution location, they are often among the first cells to come into contact with pathogens.Relevant studies have demonstrated that ILCs play an early role in the defence against a variety of pathogenic microorganisms, including bacteria, viruses, fungi and helminths, before they intervene in the adaptive immune system. ILCs can initiate a rapid, nonspecific response against pathogens prior to the initiation of an adaptive immune response and can generate a protective immune response against specific pathogens, secreting different effectors to play a role.There is growing evidence that ILCs play an important role in host control of infectious diseases. In this paper, we summarize and discuss the current known infectious diseases in which ILCs are involved and ILC contribution to the defence against infectious diseases. Further insights into the mechanisms of ILCs action in different infectious diseases will be useful in facilitating the development of therapeutic strategies for early control of infections.

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来源期刊
Innate Immunity
Innate Immunity 生物-免疫学
CiteScore
7.20
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Innate Immunity is a highly ranked, peer-reviewed scholarly journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS). The journal welcomes manuscripts from researchers actively working on all aspects of innate immunity including biologically active bacterial, viral, fungal, parasitic, and plant components, as well as relevant cells, their receptors, signaling pathways, and induced mediators. The aim of the Journal is to provide a single, interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants to researchers. The Journal creates a vehicle for the publication of articles encompassing all areas of research, basic, applied, and clinical. The subject areas of interest include, but are not limited to, research in biochemistry, biophysics, cell biology, chemistry, clinical medicine, immunology, infectious disease, microbiology, molecular biology, and pharmacology.
期刊最新文献
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