推进毛利人的微生物组研究:从最近探索代表性不足的土著人肠道微生物组的文献中获得的启示。

IF 5 2区 生物学 Q1 MICROBIOLOGY mSystems Pub Date : 2024-11-19 Epub Date: 2024-10-04 DOI:10.1128/msystems.00909-24
Ella T Silk, Simone B Bayer, Meika Foster, Nicole C Roy, Michael W Taylor, Tommi Vatanen, Richard B Gearry
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引用次数: 0

摘要

肠道微生物组对人类健康起着至关重要的作用,包括介导新陈代谢、免疫和肠道-大脑轴。由于饮食、社会经济、健康和城市化等方面的差异,许多种族在肠道微生物组研究中的代表性仍然不足,土著人和非土著人之间的差异很大。尽管有关原住民微生物组的研究在不断增加,但毛利人微生物组的文献却很缺乏,尽管毛利人普遍面临着不平等。这些不平等现象很可能会导致肠道微生物组的差异,从而加剧不良的健康后果。要为解决健康不平等问题提供信息,就必须描述代表性不足人群的肠道微生物组。然而,要使微生物组研究具有文化责任感和意义,必须改进研究设计,以更好地保护原住民的权利和利益。在此,我们将讨论原住民参与研究的障碍,以及差异在塑造原住民肠道微生物组方面可能发挥的作用,尤其关注对毛利人的影响和有待改进的领域。
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Advancing microbiome research in Māori populations: insights from recent literature exploring the gut microbiomes of underrepresented and Indigenous peoples.

The gut microbiome plays vital roles in human health, including mediating metabolism, immunity, and the gut-brain axis. Many ethnicities remain underrepresented in gut microbiome research, with significant variation between Indigenous and non-Indigenous peoples due to dietary, socioeconomic, health, and urbanization differences. Although research regarding the microbiomes of Indigenous peoples is increasing, Māori microbiome literature is lacking despite widespread inequities that Māori populations face. These inequities likely contribute to gut microbiome differences that exacerbate negative health outcomes. Characterizing the gut microbiomes of underrepresented populations is necessary to inform efforts to address health inequities. However, for microbiome research to be culturally responsible and meaningful, study design must improve to better protect the rights and interests of Indigenous peoples. Here, we discuss barriers to Indigenous participation in research and the role disparities may play in shaping the gut microbiomes of Indigenous peoples, with a particular focus on implications for Māori and areas for improvement.

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来源期刊
mSystems
mSystems Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
10.50
自引率
3.10%
发文量
308
审稿时长
13 weeks
期刊介绍: mSystems™ will publish preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems™ encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems™ will welcome submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems™ will provide streamlined decisions, while carrying on ASM''s tradition of rigorous peer review.
期刊最新文献
Association of body index with fecal microbiome in children cohorts with ethnic-geographic factor interaction: accurately using a Bayesian zero-inflated negative binomial regression model. Cigarette smoke-induced disordered microbiota aggravates the severity of influenza A virus infection. Deep learning enabled integration of tumor microenvironment microbial profiles and host gene expressions for interpretable survival subtyping in diverse types of cancers. Advancing microbiome research in Māori populations: insights from recent literature exploring the gut microbiomes of underrepresented and Indigenous peoples. Pan-genome-scale metabolic modeling of Bacillus subtilis reveals functionally distinct groups.
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