{"title":"帕金森病患者睡眠棘波的改变与认知能力下降之间的关系。","authors":"Christopher I. Villamar-Flores , Mayela Rodríguez-Violante , Arturo Abundes-Corona , Vanessa Alatriste-Booth , Matilde Valencia-Flores , Yaneth Rodríguez-Agudelo , Amín Cervantes-Arriaga , Rodolfo Solís-Vivanco","doi":"10.1016/j.neulet.2024.138006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Sleep macro and microstructural features have a relevant role for cognition. Although alterations in sleep macrostructure have been reported in persons with neurodegenerative disorders, including Parkinson’s disease (PD), it is unknown whether there is a relationship between alterations in microstructure (sleep spindles) and global cognitive deficits in this disease.</div></div><div><h3>Objective</h3><div>To explore the association between the macro and microstructure of sleep (sleep spindles) and the general cognitive state in persons with PD.</div></div><div><h3>Methods</h3><div>Thirty-three patients with idiopathic PD underwent a one-night polysomnography (PSG) and a global cognitive assessment using the Montreal Cognitive Assessment (MoCA) test. PSG-based macrostructural sleep values and quantification and spectral estimation of sleep spindles were obtained.</div></div><div><h3>Results</h3><div>We found increases in total sleep time, latency to rapid eye movement (REM) sleep, and percentage of N1 stage, as well as a decrease in percentage of REM sleep and sleep efficiency compared to values reported in healthy adults. Compared to expected values, a decrease in the number of sleep spindles was found at frontal regions. Participants with cognitive impairment showed an even lower count of sleep spindles, as well as an increase in the amplitude of underlying sigma (12–16 Hz) waves (fast spindles). When exploring MoCA subdomains, we found a consistent relationship between the number and amplitude of sleep spindles and attention capacity.</div></div><div><h3>Conclusions</h3><div>Decreased number and increased amplitude of sleep spindles are linked to cognitive impairment in persons with PD, especially in attention capacity. Therefore, sleep spindles characteristics could serve as prognostic indicators of cognitive deterioration in PD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 138006"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between alterations in sleep spindles and cognitive decline in persons with Parkinson’s disease\",\"authors\":\"Christopher I. Villamar-Flores , Mayela Rodríguez-Violante , Arturo Abundes-Corona , Vanessa Alatriste-Booth , Matilde Valencia-Flores , Yaneth Rodríguez-Agudelo , Amín Cervantes-Arriaga , Rodolfo Solís-Vivanco\",\"doi\":\"10.1016/j.neulet.2024.138006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Sleep macro and microstructural features have a relevant role for cognition. Although alterations in sleep macrostructure have been reported in persons with neurodegenerative disorders, including Parkinson’s disease (PD), it is unknown whether there is a relationship between alterations in microstructure (sleep spindles) and global cognitive deficits in this disease.</div></div><div><h3>Objective</h3><div>To explore the association between the macro and microstructure of sleep (sleep spindles) and the general cognitive state in persons with PD.</div></div><div><h3>Methods</h3><div>Thirty-three patients with idiopathic PD underwent a one-night polysomnography (PSG) and a global cognitive assessment using the Montreal Cognitive Assessment (MoCA) test. PSG-based macrostructural sleep values and quantification and spectral estimation of sleep spindles were obtained.</div></div><div><h3>Results</h3><div>We found increases in total sleep time, latency to rapid eye movement (REM) sleep, and percentage of N1 stage, as well as a decrease in percentage of REM sleep and sleep efficiency compared to values reported in healthy adults. Compared to expected values, a decrease in the number of sleep spindles was found at frontal regions. Participants with cognitive impairment showed an even lower count of sleep spindles, as well as an increase in the amplitude of underlying sigma (12–16 Hz) waves (fast spindles). When exploring MoCA subdomains, we found a consistent relationship between the number and amplitude of sleep spindles and attention capacity.</div></div><div><h3>Conclusions</h3><div>Decreased number and increased amplitude of sleep spindles are linked to cognitive impairment in persons with PD, especially in attention capacity. Therefore, sleep spindles characteristics could serve as prognostic indicators of cognitive deterioration in PD.</div></div>\",\"PeriodicalId\":19290,\"journal\":{\"name\":\"Neuroscience Letters\",\"volume\":\"842 \",\"pages\":\"Article 138006\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroscience Letters\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0304394024003859\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience Letters","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304394024003859","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Association between alterations in sleep spindles and cognitive decline in persons with Parkinson’s disease
Background
Sleep macro and microstructural features have a relevant role for cognition. Although alterations in sleep macrostructure have been reported in persons with neurodegenerative disorders, including Parkinson’s disease (PD), it is unknown whether there is a relationship between alterations in microstructure (sleep spindles) and global cognitive deficits in this disease.
Objective
To explore the association between the macro and microstructure of sleep (sleep spindles) and the general cognitive state in persons with PD.
Methods
Thirty-three patients with idiopathic PD underwent a one-night polysomnography (PSG) and a global cognitive assessment using the Montreal Cognitive Assessment (MoCA) test. PSG-based macrostructural sleep values and quantification and spectral estimation of sleep spindles were obtained.
Results
We found increases in total sleep time, latency to rapid eye movement (REM) sleep, and percentage of N1 stage, as well as a decrease in percentage of REM sleep and sleep efficiency compared to values reported in healthy adults. Compared to expected values, a decrease in the number of sleep spindles was found at frontal regions. Participants with cognitive impairment showed an even lower count of sleep spindles, as well as an increase in the amplitude of underlying sigma (12–16 Hz) waves (fast spindles). When exploring MoCA subdomains, we found a consistent relationship between the number and amplitude of sleep spindles and attention capacity.
Conclusions
Decreased number and increased amplitude of sleep spindles are linked to cognitive impairment in persons with PD, especially in attention capacity. Therefore, sleep spindles characteristics could serve as prognostic indicators of cognitive deterioration in PD.
期刊介绍：
Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.
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