用于治疗椎间盘切除术后环状纤维缺损和髓核变性的多酚改性仿生生物粘合剂。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL Acta Biomaterialia Pub Date : 2024-11-01 DOI:10.1016/j.actbio.2024.09.038
Yan Ju , Shiyuan Ma , Meimei Fu , Min Wu , Yue Li , Yue Wang , Meihan Tao , Zhihui Lu , Jinshan Guo
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引用次数: 0

摘要

椎间盘切除术是缓解椎间盘(IVD)突出引起的腰痛的外科标准疗法。然而,椎间盘纤维环(AF)缺损和髓核(NP)变性仍然存在,这往往会导致椎间盘突出症复发(再疝)。在此,我们开发了一种多酚改性水性聚氨酯生物粘合剂(PPU-胶),以促进椎间盘切除术后的治疗预后。PPU 胶水由单宁酸(TA)混合阳离子水性聚氨酯纳米分散体(TA/WPU+)和姜黄素(Cur)嵌入阴离子水性聚氨酯纳米分散体(Cur-WPU-)组成,能迅速凝胶(PPU-胶水中的+和Cur-WPU-会产生静电作用并提高粒子的堆积密度)。PPU 胶具有源自多酚的卓越的活性氧(ROS)清除能力。PPU-胶能调节变性NP细胞中细胞外基质(ECM)的新陈代谢,并能从生物学和机械学角度促进变性大鼠椎间盘的治疗。总之,本研究强调了将 AF 封闭和 NP 增强相结合的治疗方法,PPU 胶在椎间盘切除术后治疗中具有巨大的应用潜力。意义说明:目前,还没有成熟的方法来治疗椎间盘切除术后纤维环(AF)缺损和髓核(NP)变性。在此,我们开发了一种多酚改性仿生物聚氨酯生物粘合剂(PPU-胶),它具有很强的粘合强度和优异的生物活性。这种结合了颗粒填料理论和英国常春藤机制的粘附策略首先被应用于椎间盘修复领域,使 AF 密封性受益匪浅。改良后的多酚类物质加入方法赋予了 PPU 胶清除 ROS 的能力、调节 ECM 代谢的能力和抗炎特性,从而促进了 NP 的增强。因此,PPU-胶水在椎间盘切除术后治疗中取得了协同效应,其设计原理可普遍推广到其他外科用途的生物粘合剂中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy
Discectomy is the surgical standard of care to relieve low back pain caused by intervertebral disc (IVD) herniation. However, there remains annulus fibrosus (AF) defect and nucleus pulposus (NP) degeneration, which often result in recurrent herniation (re-herniation). Herein, we develop a polyphenol-modified waterborne polyurethane bioadhesives (PPU-glues) to promote therapy prognosis after discectomy. Being composed of tannic acid (TA) mixed cationic waterborne polyurethane nanodispersions (TA/WPU+) and curcumin (Cur) embedded anionic waterborne polyurethane nanodispersions (Cur-WPU-), PPU-glue gels rapidly (<10 s) and exhibits low swelling ratios, tunable degradation rates and good biocompatibility. Due to the application of an adhesion strategy combing English ivy mechanism and particle packing theory, PPU-glue also shows considerable lap shear strength against wet porcine skin (≈58 kPa) and burst pressure (≈26 kPa). The mismatched particle sizes and the opposite charges of TA/WPU+ and Cur-WPU- in PPU-glue bring electrostatic interaction and enhance particle packing density. PPU-glue possesses superior reactive oxygen species (ROS)-scavenging capacity derived from polyphenols. PPU-glue can regulate extracellular matrix (ECM) metabolism in degenerated NP cells, and it can promote therapy biologically and mechanically in degenerated rat caudal discs. In summary, this study highlights the therapeutic approach that combines AF seal and NP augmentation, and PPU-glue holds great application potentials for post discectomy therapy.

Statement of significance

Currently, there is no established method for the therapy of annulus fibrosus (AF) defect and nucleus pulposus (NP) degeneration after discectomy. Herein, we developed a polyphenol-modified biomimetic polyurethane bioadhesive (PPU-glue) with strong adhesive strength and superior bioactive property. The adhesion strategy that combined a particle packing theory and an English ivy mechanism was firstly applied to the intervertebral disc repair field, which benefited AF seal. The modified method of incorporating polyphenols was utilized to confer with ROS-scavenging capacity, ECM metabolism regulation ability and anti-inflammatory property, which promoted NP augmentation. Thus, PPU-glue attained the synergy effect for post discectomy therapy, and the design principle could be universally expanded to the bioadhesives for other surgical uses.
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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