Weiyuan Wang, Rachel J Sabol, Alexus M Day, Tamara G Hathorn, Maria N Clark, Sara E Connell, Elena A Mantis, Mariam Traore, Jacqueline M Siciliano, Emma J Arsenault, Noelle T Labrecque, Emily C Sullivan, Andrea L Cote, Paul T Toran, Brian M Barth
{"title":"肥胖促进急性髓性白血病中神经酰胺介导的 NADPH 氧化酶的形成","authors":"Weiyuan Wang, Rachel J Sabol, Alexus M Day, Tamara G Hathorn, Maria N Clark, Sara E Connell, Elena A Mantis, Mariam Traore, Jacqueline M Siciliano, Emma J Arsenault, Noelle T Labrecque, Emily C Sullivan, Andrea L Cote, Paul T Toran, Brian M Barth","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is a type of blood cancer of the myeloid cell lineage. Obesity is characterized by an increase in body weight that results in excessive fat accumulation. Obesity has been associated with an increased incidence of many cancers, including blood cancers. This study evaluated the role obesity in AML progression in a novel transgenic mouse model developed by crossing Flt3<sup>ITD</sup> mice with Lep<sup>ob/ob</sup> mice. Leukemia burden was augmented in obese AML mice. In addition, it was determined that obesity upregulated the ceramide-mediated and ceramide-1-phosphate-mediated NADPH oxidase 2 (NOX2). Notably, increased oxidative pathways has been attributed to disease progression in AML. Taken together, this study demonstrates a direct link between obesity and the progression of AML in part by augmenting the ceramide mediated NOX2.</p>","PeriodicalId":520239,"journal":{"name":"Journal of blood disorders and malignancies","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449433/pdf/","citationCount":"0","resultStr":"{\"title\":\"Obesity Promotes the Ceramide-Mediated NADPH Oxidase in Acute Myeloid Leukemia.\",\"authors\":\"Weiyuan Wang, Rachel J Sabol, Alexus M Day, Tamara G Hathorn, Maria N Clark, Sara E Connell, Elena A Mantis, Mariam Traore, Jacqueline M Siciliano, Emma J Arsenault, Noelle T Labrecque, Emily C Sullivan, Andrea L Cote, Paul T Toran, Brian M Barth\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute myeloid leukemia (AML) is a type of blood cancer of the myeloid cell lineage. Obesity is characterized by an increase in body weight that results in excessive fat accumulation. Obesity has been associated with an increased incidence of many cancers, including blood cancers. This study evaluated the role obesity in AML progression in a novel transgenic mouse model developed by crossing Flt3<sup>ITD</sup> mice with Lep<sup>ob/ob</sup> mice. Leukemia burden was augmented in obese AML mice. In addition, it was determined that obesity upregulated the ceramide-mediated and ceramide-1-phosphate-mediated NADPH oxidase 2 (NOX2). Notably, increased oxidative pathways has been attributed to disease progression in AML. Taken together, this study demonstrates a direct link between obesity and the progression of AML in part by augmenting the ceramide mediated NOX2.</p>\",\"PeriodicalId\":520239,\"journal\":{\"name\":\"Journal of blood disorders and malignancies\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449433/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of blood disorders and malignancies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of blood disorders and malignancies","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/15 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Obesity Promotes the Ceramide-Mediated NADPH Oxidase in Acute Myeloid Leukemia.
Acute myeloid leukemia (AML) is a type of blood cancer of the myeloid cell lineage. Obesity is characterized by an increase in body weight that results in excessive fat accumulation. Obesity has been associated with an increased incidence of many cancers, including blood cancers. This study evaluated the role obesity in AML progression in a novel transgenic mouse model developed by crossing Flt3ITD mice with Lepob/ob mice. Leukemia burden was augmented in obese AML mice. In addition, it was determined that obesity upregulated the ceramide-mediated and ceramide-1-phosphate-mediated NADPH oxidase 2 (NOX2). Notably, increased oxidative pathways has been attributed to disease progression in AML. Taken together, this study demonstrates a direct link between obesity and the progression of AML in part by augmenting the ceramide mediated NOX2.
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