将磷脂酰乙醇作为控制饮酒治疗的结果测量指标。

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE Alcohol and alcoholism Pub Date : 2024-09-21 DOI:10.1093/alcalc/agae070
Anders Hammarberg, Stina Ingesson Hammarberg, Susanna Redegren Cuellar, Joar Guterstam
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引用次数: 0

摘要

背景:磷脂酰乙醇(PEth)是酒精摄入量的特异性指标,既可用作危险饮酒的筛查方法,也可用作酒精使用障碍(AUD)治疗的结果测量指标。然而,在治疗过程中应用何种临界值来判定危险饮酒尚不清楚。我们的目的是调查 PEth 与自我报告饮酒之间的相关性,并确定针对 AUD 患者和以控制饮酒为既定目标的危险使用的最佳临界值:我们使用了瑞典斯德哥尔摩专业成瘾治疗机构开展的一项随机对照试验的数据,该试验针对两种不同的心理治疗方法,目的是控制饮酒。共有 181 名患者留下了可纳入本次分析的样本。在两年的随访过程中,在五个不同的时间点对结果进行了测量。结果显示,PEth 16:0/18:1值与基于时间轴回溯法的近期饮酒主观报告相关:结果:随着时间的推移,PEth 与自我报告的酒精摄入量之间的相关性显著增加,基线时的相关性最弱(Spearman's ρ = 0.42),104 周随访时的相关性最强(ρ = 0.69)。当根据瑞典指南(每周≥10个单位)来表示危险饮酒时,接收器操作特征分析表明 PEth ≥ 0.22 μmol/l 是最佳临界值:结论:PEth 是一种有用的结果测量指标,可用于验证当前饮酒的主观报告。在以控制饮酒为目的的治疗环境中,患者自我报告的准确性似乎会随着时间的推移而提高。在这种情况下,PEth 值≥0.22 μmol/l 是危险饮酒的一个敏感而特异的指标。
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Phosphatidylethanol as an outcome measure in treatment aimed at controlled drinking.

Background: Phosphatidylethanol (PEth) is a specific marker of alcohol intake, used both as a screening method for hazardous use and as an outcome measure in the treatment of alcohol use disorder (AUD). However, what cut-off values to apply for hazardous use in a treatment setting is still unclear. We aimed to investigate the correlation between PEth and self-reported drinking and identify the optimal cut-off for hazardous use, for patients with AUD and a stated goal of controlled drinking.

Methods: We used data from a randomized controlled trial of two different psychological treatments aiming for controlled drinking, conducted within specialized addiction care in Stockholm, Sweden. A total of 181 patients left samples that could be included in the current analysis. Outcomes were measured at five different time points over 2 years of follow-up. PEth 16:0/18:1 values were correlated with subjective reports of recent drinking based on the Timeline Follow-Back Method.

Results: The correlation between PEth and self-reported alcohol intake increased significantly over time, with the weakest correlation found at baseline (Spearman's ρ = 0.42) and the strongest at the 104-week follow-up (ρ = 0.69). When used to indicate hazardous drinking according to Swedish guidelines (≥10 units per week), receiver operating characteristic analysis revealed PEth ≥ 0.22 μmol/l to be the optimal cut-off.

Conclusions: PEth is a useful outcome measure that can be used to validate subjective reports of current drinking. In a treatment setting aimed at controlled drinking, the accuracy of patients' self-report measures seems to improve over time. In this context, a PEth value of ≥0.22 μmol/l is a sensitive and specific indicator of hazardous drinking.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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