产前环境与线性生长的关联机制:孕期斋月的案例。

IF 5 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH American journal of epidemiology Pub Date : 2024-10-04 DOI:10.1093/aje/kwae386
Fabienne Pradella, Reyn Ewijk
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引用次数: 0

摘要

尽管产前营养匮乏与后代生长受损之间已建立了联系,但其背后的动态变化和潜在的调节因素在很大程度上仍未得到探讨。本研究利用印度尼西亚家庭生活调查(1993-2015 年)的数据,研究了孕期斋月的基本动态及其与儿童线性生长的关系。我们利用孕期斋月作为自然实验,将暴露与母亲背景特征和出生季节效应分离开来。利用 OLS 和逻辑回归,我们探讨了医学理论预测的两个关键机制。首先,产前冲击所导致的健康损害会受到产后环境的影响。我们的研究结果表明,在卫生条件差的环境中长大的儿童主要会出现明显的生长障碍,而卫生条件差本身就是导致线性生长减弱的一个风险因素。其次,我们评估了产前斋月是否会促使表观遗传学转向更早的生殖活动,从而可能牺牲身高的增长。我们的数据显示,产前受到斋月影响的妇女倾向于在更年轻的年龄生育第一胎,尽管初潮的到来不受影响。这些结果表明,产后环境在减轻对产前冲击的敏感性方面起着至关重要的作用,突出了为所有儿童提供良好生活条件的迫切需要。
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Mechanisms linking prenatal environment and linear growth: the case of Ramadan during pregnancy.

Despite established links between prenatal nutritional deprivation and impaired offspring growth, the underlying dynamics and potential moderators remain largely unexplored. This study investigates the dynamics underlying Ramadan during pregnancy and its associations with children's linear growth, using data from the Indonesian Family Life Survey (1993 - 2015). We exploit Ramadan during pregnancy as a natural experiment, separating exposure from maternal background characteristics and season of birth effects. Employing OLS and logistic regressions, we explore two key mechanisms predicted by medical theory. First, the realization of health impairments in response to prenatal shocks is influenced by postnatal circumstances. Our results reveal significant growth impairments primarily in children raised under poor sanitary conditions, which is a risk factor for diminished linear growth by itself. Secondly, we assess whether prenatal Ramadan prompts epigenetic shifts towards earlier reproductive activity, potentially at the expense of height growth. Our data shows that prenatally exposed women tend to have their first childbirth at a younger age, though menarche onset remains unaffected. These results suggest that postnatal environments play a crucial role in mitigating sensitivity to prenatal shocks, highlighting the critical need for favorable living conditions for all children.

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来源期刊
American journal of epidemiology
American journal of epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.40
自引率
4.00%
发文量
221
审稿时长
3-6 weeks
期刊介绍: The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research. It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.
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