"探索菟丝子的治疗潜力和毒理学特征:药理学研究的启示和抗胆碱能毒性报告"。

IF 2.2 4区 医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-10-03 eCollection Date: 2024-10-01 DOI:10.1093/toxres/tfae160
Saurabh Dilip Bhandare
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引用次数: 0

摘要

本研究根据最近的药理学调查,探讨了菟丝子的治疗潜力和毒理学特征:"菟丝子的治疗潜力与毒理学风险:药理学与毒理学的两难选择"。该研究涵盖多个研究领域,包括使用菟丝子黄酮类化合物(CCFs)减轻双酚 A(BPA)诱导的卵巢损伤、菟丝子水提取物(CLW)的急性和亚急性毒性评估,以及观察菟丝子对马的毒性。此外,这项科学研究还讨论了大豆与寄生菟丝子(Cuscuta australis)在营养缺乏条件下的植物间交流动态。主要的重要发现强调了CCFs在减轻双酚A诱导的卵巢损伤方面的功效、CLW在特定剂量内的安全性概况以及菟丝子毒性在马身上的临床表现。此外,对植物间交流机制的深入研究强调了在营养缺乏的环境中蛋白质介导的相互作用的重要性。报告说明了菟丝子对人类的潜在毒性,对其化学成分和毒理学特征的进一步研究结果揭示了有关其植物毒性的大量数据。提高对食用菟丝子和其他类似植物物种相关风险的认识和理解,对于预防植物中毒至关重要,也是目前菟丝子毒理学研究的一个重要重点。因此,通过实现这些目标,这项科学研究旨在平衡菟丝子的治疗功效与其潜在的毒理学风险,从而有助于更细致地了解菟丝子在药理学和毒理学中的作用。这种双重关注对于指导未来研究和告知安全使用方法至关重要。
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"Exploring therapeutic potential and toxicological profiles of Cuscuta species: insights from pharmacological studies and an anti-cholinergic toxicity report."

This study examines the therapeutic potential and toxicological profiles of Cuscuta species based on recent pharmacological investigations: "a therapeutic potential vs. toxicological risks of Cuscuta species: a pharmacological-toxicology dilemma." The study encompasses diverse research areas, including the mitigation of Bisphenol A (BPA)-induced ovarian damage using Cuscuta chinensis flavonoids (CCFs), acute and sub-acute toxicity assessments of Cuscuta chinensis Lam. water extract (CLW), and observations on Cuscuta campestris toxicity in horses. In addition, this scientific study discusses the interplant communication dynamics between soybean and the parasitic dodder (Cuscuta australis) under nutrient deficiency conditions. Key significant findings highlight the efficacy of CCFs in alleviating BPA-induced ovarian damage, the safety profile of CLW within specified doses, and clinical manifestations of C. campestris toxicity in horses. Moreover, insights into interplant communication mechanisms emphasise the significance of protein-mediated interactions in nutrient-deficient environments. The report illustrates the potential toxicity of Dodder in humans, and further research findings into its chemical composition and toxicological profiles reveal great data on its phytotoxicity. Greater awareness and understanding of the risks associated with consuming Dodder and other similar plant species are crucial for preventing plant intoxication and have been a significant major focus of the present toxicology study of Cuscuta species. Hence, by addressing these objectives, the scientific study aims to balance the therapeutic benefits of Cuscuta species with their potential toxicological risks, contributing to a more nuanced understanding of their role in pharmacology and toxicology. This dual focus is crucial for guiding future research and informing safe usage practices.

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来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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