巨细胞病毒胎儿病的胼胝体损伤:神经超声研究。

IF 1.6 3区 医学 Q3 OBSTETRICS & GYNECOLOGY Fetal Diagnosis and Therapy Pub Date : 2024-10-04 DOI:10.1159/000541794
Karina Krajden Haratz, Gustavo Malinger, Hadas Miremberg, Joseph Hartoov, Igal Wolman, Ariel Jaffa, Michael Busilov, Roee Birnbaum
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引用次数: 0

摘要

引言 - 本研究旨在描述 CMV 胎儿病中胼胝体损伤的发生率和模式。方法 - 这项回顾性研究包括确诊为 CMV-PCR 的胎儿。进行了包括神经超声在内的专用超声检查。胼胝体长度低于第 5 百分位数或形态异常被视为异常。任何其他异常结果均需报告。结果 - 共纳入 72 例患者。76%的患者感染发生在第1胎或围产期。34.7%的患者出现胼胝体异常,但从未被分离出来。中枢神经系统异常包括:脑室周围高回声(PVHE)55.5%、钙化52%、脑室肿大33%、脑室周围假性囊肿31.4%、枕囊肿22.2%、回声前包膜生发基质30.5%、LSV26.4%、沟纹异常22.2%、小脑发现18%和HC低于-2SD18%。与CC损伤最常见的关联是PVHE(56%)和钙化(52%)。结论 - 尽管CC并不是受CMV感染影响的典型脑结构,但三分之一的患者(包括晚期感染病例)的CC受到了损伤。这些病例的发病机制和胼胝体受累的产前模式似乎与产后模式不同,且不可逆转。胼胝体损伤的存在意味着预后较差,神经发育障碍的风险显著增加。
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Callosal injuries in cytomegalovirus fetopathy: a neurosonographic study.

Introduction - This study aimed to describe the rate and pattern of callosal injury in CMV fetopathy. Methods - This retrospective study included fetuses with confirmed CMV-PCR. Dedicated US including neurosonography was performed. Callosal Length below the 5th centile or morphological abnormalities were considered abnormal. Any additional abnormal findings were reported. Results - Seventy-two patients were included. In 76% infection occurred in the 1stT or periconceptional. In 34.7% a callosal anomaly was observed and it was never isolated. CNS abnormalities included: periventricular hyperechogenicity (PVHE) 55.5%, calcifications 52%, ventriculomegaly 33%, periventricular pseudocysts 31.4%, occipital cysts 22.2%, echogenic precaudate germinal matrix 30.5%, LSV 26.4%, sulcation abnormalities 22.2%, cerebellar findings 18% and HC below -2SD 18%. The most common association with CC insult was PVHE (56%) and calcifications (52%). Conclusion - Although not referred to as a classic brain structure affected by CMV infection, the CC was injured in one-third of our patients, including cases of late infection. The mechanism of disease and the prenatal patterns of callosal involvement in these cases appear to be different from the postnatal patterns and are not reversible. The presence of a callosal injury would imply a worse prognosis and a significant increment in the risk of neurodevelopmental impairment.

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来源期刊
Fetal Diagnosis and Therapy
Fetal Diagnosis and Therapy 医学-妇产科学
CiteScore
4.70
自引率
9.10%
发文量
48
审稿时长
6-12 weeks
期刊介绍: The first journal to focus on the fetus as a patient, ''Fetal Diagnosis and Therapy'' provides a wide range of biomedical specialists with a single source of reports encompassing the common discipline of fetal medicine.
期刊最新文献
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