CAR-T细胞疗法后致命性侵袭性真菌感染的教训：病例报告和文献综述。

IF 2.7 4区医学 Q3 IMMUNOLOGY Immunotherapy Pub Date : 2024-01-01 Epub Date: 2024-10-07 DOI:10.1080/1750743X.2024.2404381

Zhengfeng Hou, Danchen Meng, Min Ruan, Xinglin Liang, Jing Ni, Dai Jifei, Zhonghui Wu, Ruixiang Xia, Jian Ge, Zhangbiao Long

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引用次数: 0

摘要

CD19 嵌合抗原受体 T（CAR-T）细胞疗法是治疗复发或难治性 B 细胞血液恶性肿瘤患者的有效方法。然而，由于该疗法的免疫抑制作用，接受CD19 CAR-T细胞疗法的患者可能会面临侵袭性真菌感染风险升高的问题，即真菌侵入宿主组织或血液，导致危及生命的感染性疾病。在本文中，我们介绍了一名被诊断为急性淋巴细胞白血病的 17 岁男性患者的病例，他在接受 CAR-T 细胞治疗后发生了致命的侵袭性真菌感染。此外，我们还深入探讨了CAR-T细胞疗法后侵袭性真菌感染的风险因素识别、预防措施实施和治疗干预措施探索。

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A lesson from fatal invasive fungal infections after CAR-T cell therapy: a case report and literature review.

CD19 chimeric antigen receptor T (CAR-T) cell therapy represents an effective approach to treating patients with relapsed or refractory B-cell hematologic malignancies. Nevertheless, owing to the immunosuppressive effects of this regimen, patients undergoing CD19 CAR-T cell therapy may face an elevated risk of invasive fungal infections, which involve fungi penetrating the host's tissues or bloodstream, leading to life-threating infectious diseases. Herein, we present the case of a 17-year-old male diagnosed with acute lymphoblastic leukemia, who subsequently experienced a fatal invasive fungal infection following administration of CAR-T cell therapy. Furthermore, we delve into the identification of risk factors, implementation of preventive measures and exploration of therapeutic interventions for invasive fungal infections after CAR-T cell therapy.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.