Ilham Badrane, Luca Urso, Alfredo Campennì, Corrado Cittanti, Maria Luisa De Rimini, Mirco Bartolomei
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引用次数: 0
摘要
放射配体疗法(RLT)于2017年获得欧洲药品管理局(EMA)批准,2018年获得美国食品药品管理局(FDA)批准,从而被广泛应用于神经内分泌肿瘤(NENs)的治疗管理。不过,目前的适应症仅限于属于更广泛的神经内分泌肿瘤家族的某些特定组织类型,主要是晚期分化良好的胃肠胰腺神经内分泌肿瘤。因此,NEN谱系中其他几种因其生物学特征而有可能从RLT中获益的肿瘤仍不符合条件,可被视为 "RLT-orphans"。在这些肿瘤中,源自交感-肾上腺-髓质(SAM)轴的 NENs 亚群可以列入其中。本文讨论了嗜铬细胞瘤和副神经节瘤的放射治疗应用现状和前景,既考虑了传统的放射治疗模式(使用放射性标记的偏碘苄基胍(MIBG)),也考虑了使用放射性标记的体生长激素类似物(SSA)的创新模式,希望在不久的将来这些患者也能使用这种治疗方法。
Radioligand therapy in sympathetic-adrenal-medullary axis tumors: state of art and perspectives.
The approval in 2017 by the European Medicines Agency (EMA) and in 2018 by the US Food and Drug Administration (FDA) of radioligand therapy (RLT) led to its wide application in therapeutic management of neuroendocrine neoplasms (NENs). However, the indications are currently limited to certain specific histotypes belonging to the broader NEN's family, mainly advanced well-differentiated gastro-entero-pancreatic NENs. As a consequence, several other tumors of the NEN spectrum that can potentially benefit, due to their biological characteristics, from RLT are still ineligible and can be considered "RLT-orphans". Among those, the subgroup of NENs originating from the sympathetic-adrenal-medullary (SAM) axis can be listed. This paper discusses the state of art and perspectives of the theragnostic applications in pheochromocytomas and paragangliomas, considering both the traditional theragnostic model - with radiolabelled metaiodobenzylguanidine (MIBG) - and the innovative one with radiolabeled somatostatin analogs (SSAs), that will hopefully become available for these patients in the near future.
期刊介绍:
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.