血清葡萄糖/钾比率作为急性一氧化碳中毒早期和延迟预后的指标。

IF 2.2 4区 医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-10-07 eCollection Date: 2024-10-01 DOI:10.1093/toxres/tfae168
Alshaimma Mahmoud Elmansy, Dalia Mustafa Hannora, Heba K Khalifa
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引用次数: 0

摘要

背景:目的:本研究旨在评估血清葡萄糖/钾(Glu/K)比值作为急性一氧化碳中毒早期和延迟不良后果快速预测指标的有效性:这项前瞻性队列研究纳入了 2023 年 1 月至 2024 年 6 月期间埃及坦塔中毒控制中心收治的 136 名急性一氧化碳中毒患者。研究计算了所有患者的血清 Glu/K 比值。主要结果是预测死亡率。次要结果是预测接触一氧化碳后 6 个月内的迟发性神经系统后遗症 (DNS)、机械通气需求和高压氧需求。应用接收器操作曲线分析法检验了 Glu/K 比值在预测急性一氧化碳中毒结果方面的性能:结果:急性 CO 中毒患者的死亡率为 12.5%。同时,14.7%的患者出现 DNS。此外,16.9%的患者需要进行机械通气。Glu/K比值升高与急性一氧化碳中毒的严重程度明显相关。在临界值大于 31.62 时,Glu/K 比值预测死亡率的 AUC 为 0.649。采用 Glu/K 比值预测 DNS 的临界值为 33.10,灵敏度为 60.0%,特异度为 82.76%,AUC 为 0.692:早期 Glu/K 比值可能是预测急性 CO 中毒患者死亡率、DNS 和机械通气需求的有效、可靠和便捷的实验室指标。
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Serum glucose/potassium ratio as an indicator of early and delayed outcomes of acute carbon monoxide poisoning.

Background: Carbon monoxide (CO) poisoning is a major health problem associated with a high rate of severe morbidity and mortality.

Aims: This study aimed to evaluate the validity of the serum glucose/potassium (Glu/K) ratio as a quick predictor of both early and delayed unfavorable outcomes following acute CO poisoning.

Patients and methods: This prospective cohort study included 136 patients with acute CO poisoning admitted at Tanta Poison Control Center, Egypt, between January 2023 and June 2024. The serum Glu/K ratio was calculated for all patients. The primary outcome was a prediction of mortality. Secondary outcomes were the prediction of delayed neurological sequelae (DNS) within six months after CO exposure, the need for mechanical ventilation, and the need for hyperbaric oxygen. A receiver operating curve analysis was applied to test the performance of the Glu/K ratio in predicting acute CO poisoning outcomes.

Results: The mortality rate was 12.5% of patients with acute CO poisoning. Meanwhile, 14.7% of patients developed DNS. Furthermore, mechanical ventilation was required in 16.9% of patients. An elevated Glu/K ratio was significantly associated with the severity of acute CO poisoning. At a cut-off value of >31.62, the Glu/K ratio demonstrated an AUC of 0.649 for predicting mortality. The Glu/K ratio was employed to predict DNS at a cut-off value of 33.10, with a sensitivity of 60.0%, a specificity of 82.76%, and an AUC of 0.692.

Conclusions: Early Glu/K ratio may be an effective, reliable, and convenient laboratory predictor of mortality, DNS, and the need for mechanical ventilation in patients with acute CO poisoning.

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来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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