抗生素暴露与新发溃疡性结肠炎的风险：系统回顾与元分析。

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-10-01 DOI:10.7754/Clin.Lab.2024.240312

Jian-Kang Zhu, Ayinuer Wubulikasimu, Gulipiye Ainiwaer, Aikepaer Aiken, Hasiyeti Aili, Ji-Lin Wang

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引用次数: 0

摘要

背景：据报道，抗生素暴露是溃疡性结肠炎发病的一个风险因素；然而，临床结果却存在争议。因此，我们进行了一项荟萃分析，以评估抗生素暴露与新发溃疡性结肠炎的关系：方法：使用 Medline 和 Embase 对截至 2024 年 2 月发表的相关文献进行全面检索，探讨抗生素暴露与新发 UC 之间的关系，并使用 Stata 软件进行统计分析：研究共纳入16篇文章，包括12项病例对照研究和4项队列研究。汇总分析显示，抗生素暴露与新发 UC 风险增加有关（汇总 OR = 1.28，95% CI = 1.26 - 1.31）。分组分析表明，病例对照研究和队列研究得出的结论是一致的：这项荟萃分析表明，接触抗生素是罹患 UC 的一个危险因素。因此，有必要避免不必要和过度使用抗生素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibiotic Exposure and Risk of New-Onset Ulcerative Colitis: a Systematic Review and Meta-Analysis.

Background: Antibiotic exposure has been reported as a risk factor for the development of ulcerative colitis; however, the clinical results were controversial. Therefore, we performed a meta-analysis to evaluate the association of antibiotic exposure with the new onset of UC.

Methods: A comprehensive literature search for relevant studies published up to February 2024, exploring the association between antibiotic exposure and new-onset UC, was performed by using Medline and Embase, and the statistical analysis was conducted by using the Stata software.

Results: A total of 16 articles were included in the study, including 12 case-control studies and 4 cohort studies. The pooled analysis revealed that antibiotic exposure was associated with an increased risk of new-onset UC (summary OR = 1.28, 95% CI = 1.26 - 1.31). Subgroup analyses showed that both case-control studies and cohort studies have yielded consistent conclusions.

Conclusions: This meta-analysis suggests that antibiotic exposure is a risk factor for the development of UC. It is, therefore, necessary to avoid unnecessary and excessive use of antibiotics.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.