利用 Cu@KF/Clinoptilolite NPs 以头孢克肟绿色合成新的氨基噻唑衍生物并去除水环境中的有机污染物。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS Combinatorial chemistry & high throughput screening Pub Date : 2024-10-07 DOI:10.2174/0113862073298128240918110357
Fariba Zamani-Hargalani, Faezeh Shafaei
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引用次数: 0

摘要

目的和目标:本研究以 Cu@KF/CP NPs 为催化剂,以水为溶剂,在室温下进行了头孢克肟、异硫氰酸盐和烷基溴化物的多组分反应,高产率合成了新的亚氨基噻唑衍生物。此外,还研究了 Cu@KF/Clinoptilolite 纳米粒子(NPs)吸附和去除水中 4-NP 和头孢克肟的能力。Cu@KF/Clinoptilolite 纳米粒子是利用杂交矮牵牛根茎的水提取物合成的:在本实验中,所有从 Fluka 和 Merck 公司获得的成分都经过了进一步纯化。本研究中使用的抗生素头孢克肟是从位于伊朗马赞达兰州萨里的一家制药厂获得的。该抗生素工厂位于伊朗萨里市。所有溶液均使用蒸馏水配制。使用 Holland Philips XL30 扫描电子显微镜获得的图像分析了 Cu@KF/CP 纳米粒子的形状。对 Cu@KF/CP 纳米粒子(NPs)的结晶结构进行了分析,并使用 Holland Philips Xpert X 射线粉末衍射仪进行了室温 X 射线衍射(XRD)检查。X 射线衍射 (XRD) 分析是使用波长为 0.15406 纳米的 CuK 辐射进行的。分析的 2ε 角范围为 20 至 80°。利用 S3700N 设备的 X 射线能量色散光谱(EDS)对制备的纳米结构进行了化学分析。使用加速电压为 90 kV 的飞利浦 EM208 透射电子显微镜对 Cu@KF/CP 纳米粒子的形态和尺寸进行了表征:本研究的主要目的是开发一种生产新型亚氨基噻唑衍生物 4 的可持续方法。这一目标是通过结合头孢克肟 1、异硫氰酸盐 2 和烷基溴化物 3 的高效三组分反应实现的。反应在常温水中进行,使用 Cu@KF/CP NPs 作为高效催化剂,从而获得了极佳的产率。此外,研究结果表明,与传统抗氧化剂相比,合成的化合物具有显著的抗氧化活性。研究还评估了合成化合物对革兰氏阳性菌和革兰氏阴性菌的抗菌效果。此外,还利用 Cu@KF/CP 纳米颗粒吸附了水基溶液中的 CFX 和 4-NP:本研究展示了通过使用多组分反应有效合成创新型亚氨基噻唑衍生物的方法,其中涉及头孢克肟、异硫氰酸盐和烷基溴化物的组合。反应在水基溶剂中进行。反应在室温下进行,使用 Cu@KF/CP NPs 作为催化剂。利用 X 射线衍射 (XRD)、场发射扫描电子显微镜 (FESEM)、能量色散 X 射线光谱 (EDX) 和透射电子显微镜 (TEM) 等研究技术合成并评估了新开发的异相纳米催化剂 Cu@KF/CP 纳米粒子。Cu@KF/CP 纳米粒子用于吸附水基溶液中的 CFX 和 4-NP。纳米颗粒的制造方法简单易行。经测量,Cu@KF/CP 纳米粒子的 BET 表面积为 201.8 m2/g。实验平衡数据通过应用 Langmuir、Freundlich、Dubinin-Radushkevich 和 Redlich-Peterson 等温线模型进行了评估。此外,我们还考察了 Cu@KF/CP 纳米粒子(NPs)在还原水中各种颜色时的催化效率。
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Green Synthesis of New Derivatives of Iminothiazole Using Cefixime and Removing Organic Pollutants from Aqueous Environment by Employing Cu@KF/Clinoptilolite NPs.

Aims and objective: In this research, multicomponent reactions of cefixime, isothiocyanates, and alkyl bromides were carried out for the synthesis of new iminothiazole derivatives with high yields in water as the solvent at room temperature in the presence of catalytic amounts of Cu@KF/CP NPs as catalysts. Also, the ability of Cu@KF/Clinoptilolite nanoparticles (NPs) to adsorb and remove 4-NP and cefixime from water was investigated. The Cu@KF/Clinoptilolite nanoparticles were synthesized by employing a water extract of Petasites hybridus rhizomes.

Materials and methods: For this experiment, all of the components obtained from Fluka and Merck were subjected to further purification. The antibiotic used in this investigation, cefixime, was obtained from a pharmaceutical facility situated in Sari, Mazandaran, Iran. The antibiotic factory is located in Sari City, Iran. All solutions were prepared using distilled water. The shape of Cu@KF/CP nanoparticles was analyzed using images obtained from a Holland Philips XL30 scanning electron microscope. An analysis was performed on the crystalline structure of Cu@KF/CP nanoparticles (NPs), and a room temperature X-ray diffraction (XRD) examination was carried out utilizing a Holland Philips Xpert X-ray powder diffractometer. The X-ray diffraction (XRD) examination was conducted using CuK radiation, which has a wavelength of 0.15406 nm. The analysis covered a 2ε angle range from 20 to 80°. The nanostructures that were produced were chemically analyzed using X-ray energy dispersive spectroscopy (EDS) with an S3700N equipment. The morphology and dimensions of Cu@KF/CP nanoparticles were characterized using a Philips EM208 transmission electron microscope operated at an acceleration voltage of 90 kV.

Results: The primary objective of this study was to develop a sustainable approach for producing new iminothiazole derivatives 4. This was achieved using a highly efficient three-component reaction combining cefixime 1, isothiocyanates 2, and alkyl bromides 3. The reaction was carried out in water at ambient temperature, using Cu@KF/CP NPs as a highly effective catalyst, leading to excellent yields. Moreover, the study findings showed that the synthesized compounds demonstrated a significant antioxidant activity compared to conventional antioxidants. The antibacterial efficacy of the synthesized compounds was evaluated against both Gram-positive and Gram-negative bacteria. Furthermore, Cu@KF/CP nanoparticles were utilized to adsorb CFX and 4-NP from water-based solutions.

Conclusion: This study showcases the effective synthesis of innovative iminothiazole derivatives through the use of multicomponent reactions, involving the combination of cefixime, isothiocyanates, and alkyl bromides. The reactions were conducted in a water-based solvent. The reactions were carried out at room temperature, utilizing Cu@KF/CP NPs as catalysts. The Cu@KF/CP nanoparticles, a newly developed heterogeneous nanocatalyst, were synthesized and evaluated utilizing X-ray diffraction (XRD), fieldemission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) research techniques. Cu@KF/CP nanoparticles are utilized to adsorb CFX and 4-NP from water-based solutions. The objects were manufactured using a straightforward and uncomplicated approach. The BET surface area of Cu@KF/CP NPs was measured to be 201.8 m2/g. The experimental equilibrium data was evaluated by applying the isotherms of the Langmuir, Freundlich, Dubinin-Radushkevich, and Redlich-Peterson models. Additionally, we examined the catalytic efficiency of Cu@KF/CP nanoparticles (NPs) in reducing various colors in water.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
327
审稿时长
7.5 months
期刊介绍: Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.
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