CX3CR1+CD8+ T 细胞：抗肿瘤免疫的关键角色

IF 5.7 2区医学 Q1 Medicine Cancer Science Pub Date : 2024-10-08 DOI:10.1111/cas.16359

Jiajin Ma, Yue Wu, Shaoxian Wu, Zhang Fang, Lujun Chen, Jingting Jiang, Xiao Zheng

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引用次数: 0

摘要

CX3CR1 是趋化因子 CX3CL1 的特异性受体，在多种免疫细胞中均有表达。这突显了它在免疫系统的交流和反应机制中的关键作用。与 CX3CL1 接触后，CX3CR1 会启动一系列下游信号通路，从而调节各种生物功能。在肿瘤进展的背景下，肿瘤微环境的复杂性和抑制性对目前的临床治疗技术提出了重大挑战。本综述旨在全面探讨 CX3CR1+CD8+ T 细胞对肿瘤的破坏潜力。同时，它还探讨了在未来肿瘤免疫疗法中利用 CX3CR1 的广阔前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CX3CR1⁺CD8⁺ T cells: Key players in antitumor immunity.

CX3CR1 functions as the specific receptor for the chemokine CX3CL1, demonstrating expression across a broad spectrum of immune cells. This underscores its pivotal role in communication and response mechanisms within the immune system. Upon engagement with CX3CL1, CX3CR1 initiates a cascade of downstream signaling pathways that regulate various biological functions. In the context of tumor progression, the intricate and inhibitory nature of the tumor microenvironment presents a significant challenge to current clinical treatment techniques. This review aims to comprehensively explore the tumor-destructive potential shown by CX3CR1⁺CD8⁺ T cells. Simultaneously, it investigates the promising prospects of utilizing CX3CR1 in future tumor immunotherapies.

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.