肌营养不良症神经精神障碍发病率及其与发病关系的荟萃分析。

IF 2.6 4区 医学 Q3 NEUROSCIENCES Acta Neuropsychiatrica Pub Date : 2024-10-08 DOI:10.1017/neu.2024.27
Carlos Pascual-Morena, Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Celia Álvarez-Bueno, Maribel Lucerón-Lucas-Torres, Alicia Saz-Lara, Irene Martínez-García
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引用次数: 0

摘要

肌营养不良症1型和2型(DM1和DM2)的神经精神障碍发病率很高,包括DM1中的自闭症谱系障碍(ASD)和注意缺陷多动障碍(ADHD),以及两种DM中的抑郁症和焦虑症。本系统综述和荟萃分析旨在估算自闭症谱系障碍、多动症、抑郁和焦虑症在 DM 患者中的患病率及其与发病的关系。我们对 Medline、Scopus、Web of Science 和 Cochrane 图书馆进行了系统性检索,检索时间从开始到 2023 年 11 月。研究纳入了估计这些疾病在 DM1 或 DM2 中发病率的观察性研究。对这些疾病的患病率进行了荟萃分析,并通过患病率比值荟萃分析对这些疾病的发病进行了关联研究。共纳入 38 项研究。在DM1中,ASD的发病率为14%,先天性发病率比青少年发病率高79%;ADHD的发病率为21%,先天性发病率和青少年发病率没有差异;抑郁症和焦虑症的发病率分别为14%和16%。抑郁症在成人发病中更为常见。最后,DM2 的抑郁症发病率为 16%。与普通人群相比,DM1 和 DM2 患者的神经精神疾病发病率更高。因此,积极筛查DM1的先天性和幼年期神经发育障碍以及DM1和DM2的情绪障碍可提高患者的生活质量。
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A meta-analysis of the prevalence of neuropsychiatric disorders and their association with disease onset in myotonic dystrophy.

There is a high prevalence of neuropsychiatric disorders in myotonic dystrophy types 1 and 2 (DM1 and DM2), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in DM1, and depression and anxiety in both DMs. The aim of this systematic review and meta-analysis was to estimate the prevalence of ASD, ADHD, depression and anxiety in the population with DM, and their association with disease onset. A systematic search of Medline, Scopus, Web of Science, and the Cochrane Library was conducted from inception to November 2023. Observational studies estimating the prevalence of these disorders in DM1 or DM2 were included. A meta-analysis of the prevalence of these disorders and an association study with disease onset by prevalence ratio meta-analysis were performed. Thirty-eight studies were included. In DM1, the prevalence of ASD was 14%, with congenital onset being 79% more common than juvenile onset, while the prevalence of ADHD was 21%, with no difference between congenital and juvenile onset, and the prevalence of depression and anxiety were 14% and 16%. Depression was more common in the adult onset. Finally, the prevalence of depression in DM2 was 16%. A higher prevalence of neuropsychiatric disorders is observed in individuals with DM1 and DM2 than in the general population. Therefore, actively screening for congenital and juvenile neurodevelopmental disorders in DM1 and emotional disorders in DM1 and DM2 may improve the quality of life of those affected.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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