胃 MALT 淋巴瘤的长期疗效和预后因素

IF 3.2 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Gastric Cancer Pub Date : 2024-10-01 DOI:10.5230/jgc.2024.24.e36
Jae Yeon Sim, Hyun Soo Chung, Sang Gyun Kim, Soo Jeong Cho, Bo Kyung Kim, Jun Shik Hong, In Ho Kim
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引用次数: 0

摘要

目的:本研究旨在评估胃黏膜相关淋巴组织(MALT)淋巴瘤患者的长期预后,包括总生存率(OS)、缓解率以及与侵袭性病程相关的因素:回顾性分析2013年至2020年间确诊的153例胃MALT淋巴瘤患者的病历。将出现复发、进展、高级别转化或残留疾病的患者纳入侵袭性组,并与惰性组患者进行比较。此外,还回顾了幽门螺旋杆菌阴性患者的内镜检查结果:患者特征如下:平均年龄(56.9±11.2 岁)、性别(男性,51.0%)、幽门螺杆菌感染(阳性,79.7%)、内镜位置(远端,89.5%)、内镜特征(浅表,89.5%)、临床分期(I 期,92.8%)、内镜超声侵犯深度(粘膜,n=115,75.7%)和骨髓结果(无受累,n=77,100.0%)。中位随访期为59个月(平均61个月;范围36-124),持续缓解期(n=149)为51个月(平均50个月;范围3-112)。5年生存率为97.7%,5年持续缓解率为88.3%。侵袭性组患者的相关因素包括年龄大、性别(男性)和临床分期为 II 期或以上。幽门螺杆菌阴性患者的内镜检查显示,胃窦部萎缩性胃炎的发生率较高:结论:胃MALT淋巴瘤的长期预后似乎并不乐观,5年生存率和持续缓解率表明了这一点。侵袭性病变与年龄、性别(男性)和临床分期II期或更高有关,但与OS无关。
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Long-term Outcomes and Prognostic Factors of Gastric MALT Lymphoma.

Purpose: This study aimed to evaluate the long-term prognosis of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, including overall survival (OS), remission, and factors associated with an aggressive disease course.

Materials and methods: Medical records of 153 patients diagnosed with gastric MALT lymphoma between 2013 and 2020 were retrospectively reviewed. Patients experiencing relapse, progression, high-grade transformation, or residual diseasewere included in the aggressive group and were compared with those in the indolent group. Additionally, the endoscopic findings of Helicobacter pylori-negative patients were reviewed.

Results: Patient characteristics were as follows: mean age (56.9±11.2 years), sex (male, 51.0%), H. pylori infection (positive, 79.7%), endoscopic location (distal, 89.5%), endoscopic feature (superficial, 89.5%), clinical stage (stage I, 92.8%), invasion depth by endoscopic ultrasound (mucosa, n=115, 75.7%), and bone marrow result (no involvement, n=77, 100.0%). The median follow-up period was 59 months (mean, 61; range, 36-124) and the continuous remission period (n=149) was 51 months (mean, 50; range, 3-112). The 5-year survival rate was 97.7% while the 5-year continuous remission was 88.3%. Factors associated with the patients in the aggressive group were old age, sex(male), and clinical stage II or higher. H. pylori-negative patients' endoscopy revealed a high incidence of atrophic gastritis in the antrum.

Conclusions: The long-term prognosis of gastric MALT lymphoma appears indolent and is indicated by the 5-year OS and continuous remission rates. Aggressive disease courses are associated with old age, sex (male), and clinical stage II or higher, but are not related to OS.

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来源期刊
Journal of Gastric Cancer
Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
4.30
自引率
12.00%
发文量
36
期刊介绍: The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.
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