改良神灵白术散治疗非小细胞肺癌靶向治疗引起的腹泻的临床价值

Wang Ming, Zheng Yun
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引用次数: 0

摘要

目的评估改良神灵白术粉(SBP)在干预靶向治疗引起的腹泻中的临床价值:本研究为前瞻性随机对照研究。85 名服用靶向药物的非小细胞肺癌(NSCLC)腹泻患者被随机分为两组。实验组服用改良 SBP,对照组服用易蒙停。在2个疗程(1周/疗程)和2周的随访中,我们观察了两组患者腹泻的缓解和复发情况,以及Karnofsky评分(KPS)的改善情况和用药安全性:共完成 80 例治疗,其中实验组 40 例,对照组 40 例。对照组腹泻缓解率明显低于实验组(PPPP>0.05)。实验组和对照组均未发生特殊不良反应:改良SBP可改善靶向治疗诱发的NSCLC腹泻,在缓解腹泻、改善相关症状评分和症状方面优于易蒙停,且无明显药物相关不良反应。
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Clinical value of modified Shenling Baizhu powder in treating targeted therapy-induced diarrhea in non-small cell lung cancer.

Objective: To assess clinical value of modified Shenling Baizhu powder (, SBP) in intervening targeted therapy-induced diarrhea.

Methods: This study was a prospective randomized controlled study. Eighty-five non-small cell lung cancer (NSCLC) patients with diarrhea who took targeted drugs were randomly divided into two groups. The experimental group received modified SBP, while the control group received imodium. During 2 courses of treatment (1 week/course) and 2 weeks of follow-up, we observed remission and recurrence of diarrhea, as well as the improvement of Karnofsky score (KPS) in the two groups and drug safety.

Results: Eighty cases were completed, with 40 cases in the experimental group and 40 cases in the control group. The control group's diarrhea remission rate was significantly lower than the experimental group's (P<0.05). After 2 courses of treatment, the symptom scores of both groups were lower than before, with that of the experimental group remarkably lower (P<0.05). Furthermore, the experimental group experienced less abdominal fullness and appetite loss than the control group (P<0.05). There was no prominent difference in overall diarrhea recurrence, time, or KPS after treatment between the two groups (P>0.05). No unique adverse events occurred in experimental group or control group.

Conclusion: The modified SBP could improve targeted therapy-induced diarrhea in NSCLC, and is superior to imodium in relieving diarrhea, improving related symptom scores and symptoms, with no obvious drug-related adverse events.

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