Hendri Susilo, Budi S Pikir, Nathanael J Tjipta, Mochamad Y Alsagaff, Mochammad Thaha, Satriyo D Suryantoro, Citrawati Dk Wungu, Mochamad Amin, Derren D Rampengan, Roy N Ramadhan, Platon Papageorgiou, Ryan Gauci, Rebeka Tóthová
{"title":"血管紧张素 II 1 型受体和骨保护蛋白基因多态性对心血管死亡风险和慢性肾脏病进展风险的影响分析。","authors":"Hendri Susilo, Budi S Pikir, Nathanael J Tjipta, Mochamad Y Alsagaff, Mochammad Thaha, Satriyo D Suryantoro, Citrawati Dk Wungu, Mochamad Amin, Derren D Rampengan, Roy N Ramadhan, Platon Papageorgiou, Ryan Gauci, Rebeka Tóthová","doi":"10.23736/S0026-4806.24.09435-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a significant global public health issue with increased risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular mortality. Single nucleotide polymorphisms (SNPs) on angiotensin II type 1 receptor (AT1R) A1166C and osteoprotegerin (OPG) C950T gene have received significant attention as a genetic risk factor for cardiovascular disease and CKD.</p><p><strong>Methods: </strong>This was a cross-sectional study involving 75 adults with CKD recruited from Nephrology Outpatient Clinics of Universitas Airlangga Hospital, Surabaya, Indonesia. Demographic data was obtained from interviews and medical records. The \"CKD Patch\" application was used to asses ASCVD and cardiovascular mortality risk scores. Statistical analysis was performed by using SPSS version 26.</p><p><strong>Results: </strong>We detected four different AT1R gene polymorphisms (A1166C, A1160C, G1170T, and G1181C) and two OPG gene polymorphisms (T950C and G1181C) in Indonesian CKD patients. A1160C and G1181C polymorphisms were novel SNPs, newly discovered in this research. No significant association was found between AT1R SNPs and kidney prognostic markers or ASCVD risk/mortality risk scores. However, for OPG C950T we found that TT genotype had a significantly higher ACR than TC or CC genotype (P=0.032). As for OPG G1181C, we found that GG genotype had a higher serum creatinine and albumin to creatinine ratio compared to GC and CC genotypes (P=0.004 and 0.029, respectively). Genotype GC for OPG G1181C was also shown to be protective for having better kidney markers and lowest cardiovascular mortality risk compared to GG and CC genotypes (P=0.018 and 0.032, respectively).</p><p><strong>Conclusions: </strong>Increased ASCVD risk and mortality risk score was not found on individuals with AT1R gene SNPs. However, for OPG gene polymorphism, C950T and G1181C were associated with kidney progression and cardiovascular mortality.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of angiotensin II type 1 receptor and osteoprotegerin gene polymorphism on the risk of cardiovascular mortality risk and progressivity of chronic kidney disease.\",\"authors\":\"Hendri Susilo, Budi S Pikir, Nathanael J Tjipta, Mochamad Y Alsagaff, Mochammad Thaha, Satriyo D Suryantoro, Citrawati Dk Wungu, Mochamad Amin, Derren D Rampengan, Roy N Ramadhan, Platon Papageorgiou, Ryan Gauci, Rebeka Tóthová\",\"doi\":\"10.23736/S0026-4806.24.09435-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a significant global public health issue with increased risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular mortality. Single nucleotide polymorphisms (SNPs) on angiotensin II type 1 receptor (AT1R) A1166C and osteoprotegerin (OPG) C950T gene have received significant attention as a genetic risk factor for cardiovascular disease and CKD.</p><p><strong>Methods: </strong>This was a cross-sectional study involving 75 adults with CKD recruited from Nephrology Outpatient Clinics of Universitas Airlangga Hospital, Surabaya, Indonesia. Demographic data was obtained from interviews and medical records. The \\\"CKD Patch\\\" application was used to asses ASCVD and cardiovascular mortality risk scores. Statistical analysis was performed by using SPSS version 26.</p><p><strong>Results: </strong>We detected four different AT1R gene polymorphisms (A1166C, A1160C, G1170T, and G1181C) and two OPG gene polymorphisms (T950C and G1181C) in Indonesian CKD patients. A1160C and G1181C polymorphisms were novel SNPs, newly discovered in this research. No significant association was found between AT1R SNPs and kidney prognostic markers or ASCVD risk/mortality risk scores. However, for OPG C950T we found that TT genotype had a significantly higher ACR than TC or CC genotype (P=0.032). As for OPG G1181C, we found that GG genotype had a higher serum creatinine and albumin to creatinine ratio compared to GC and CC genotypes (P=0.004 and 0.029, respectively). Genotype GC for OPG G1181C was also shown to be protective for having better kidney markers and lowest cardiovascular mortality risk compared to GG and CC genotypes (P=0.018 and 0.032, respectively).</p><p><strong>Conclusions: </strong>Increased ASCVD risk and mortality risk score was not found on individuals with AT1R gene SNPs. However, for OPG gene polymorphism, C950T and G1181C were associated with kidney progression and cardiovascular mortality.</p>\",\"PeriodicalId\":94143,\"journal\":{\"name\":\"Minerva medica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Minerva medica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23736/S0026-4806.24.09435-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva medica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S0026-4806.24.09435-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：慢性肾脏病（CKD）是一个重要的全球性公共卫生问题，它增加了动脉粥样硬化性心血管疾病（ASCVD）和心血管死亡的风险。血管紧张素 II 1 型受体（AT1R）A1166C 和骨保护蛋白（OPG）C950T 基因上的单核苷酸多态性（SNPs）作为心血管疾病和 CKD 的遗传风险因素受到了广泛关注：这是一项横断面研究，从印度尼西亚泗水 Universitas Airlangga 医院肾脏病门诊部招募了 75 名患有慢性肾脏病的成年人。人口统计学数据来自访谈和医疗记录。使用 "CKD Patch "应用软件来评估ASCVD和心血管死亡风险评分。统计分析采用 SPSS 26 版本：结果：我们在印尼的 CKD 患者中发现了四种不同的 AT1R 基因多态性（A1166C、A1160C、G1170T 和 G1181C）和两种 OPG 基因多态性（T950C 和 G1181C）。A1160C和G1181C多态性是本研究新发现的新型SNPs。在 AT1R SNP 与肾脏预后指标或 ASCVD 风险/死亡风险评分之间没有发现明显的关联。然而，我们发现 OPG C950T 的 TT 基因型的 ACR 明显高于 TC 或 CC 基因型（P=0.032）。至于 OPG G1181C，我们发现与 GC 和 CC 基因型相比，GG 基因型的血清肌酐和白蛋白肌酐比值更高（P=0.004 和 0.029）。与 GG 和 CC 基因型相比，OPG G1181C 的 GC 基因型对肾脏指标和最低心血管死亡风险也有保护作用（P=0.018 和 0.032）：结论：在具有 AT1R 基因 SNP 的个体中，并未发现 ASCVD 风险和死亡风险评分增加的现象。结论：未发现AT1R基因多态性会增加ASCVD风险和死亡率风险评分，但OPG基因多态性中，C950T和G1181C与肾脏恶化和心血管疾病死亡率有关。
Analysis of angiotensin II type 1 receptor and osteoprotegerin gene polymorphism on the risk of cardiovascular mortality risk and progressivity of chronic kidney disease.
Background: Chronic kidney disease (CKD) is a significant global public health issue with increased risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular mortality. Single nucleotide polymorphisms (SNPs) on angiotensin II type 1 receptor (AT1R) A1166C and osteoprotegerin (OPG) C950T gene have received significant attention as a genetic risk factor for cardiovascular disease and CKD.
Methods: This was a cross-sectional study involving 75 adults with CKD recruited from Nephrology Outpatient Clinics of Universitas Airlangga Hospital, Surabaya, Indonesia. Demographic data was obtained from interviews and medical records. The "CKD Patch" application was used to asses ASCVD and cardiovascular mortality risk scores. Statistical analysis was performed by using SPSS version 26.
Results: We detected four different AT1R gene polymorphisms (A1166C, A1160C, G1170T, and G1181C) and two OPG gene polymorphisms (T950C and G1181C) in Indonesian CKD patients. A1160C and G1181C polymorphisms were novel SNPs, newly discovered in this research. No significant association was found between AT1R SNPs and kidney prognostic markers or ASCVD risk/mortality risk scores. However, for OPG C950T we found that TT genotype had a significantly higher ACR than TC or CC genotype (P=0.032). As for OPG G1181C, we found that GG genotype had a higher serum creatinine and albumin to creatinine ratio compared to GC and CC genotypes (P=0.004 and 0.029, respectively). Genotype GC for OPG G1181C was also shown to be protective for having better kidney markers and lowest cardiovascular mortality risk compared to GG and CC genotypes (P=0.018 and 0.032, respectively).
Conclusions: Increased ASCVD risk and mortality risk score was not found on individuals with AT1R gene SNPs. However, for OPG gene polymorphism, C950T and G1181C were associated with kidney progression and cardiovascular mortality.
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