Ai-Qiu Liao, Juan Wen, Jing-Chen Wei, Bing-Bing Xu, Nan Jin, Hong-Yu Lin, Xiu-Ying Qin
{"title":"磺酰胺衍生物铜 (II) 基配合物的合成、晶体结构及其通过抗血管生成、抗炎、促凋亡和杯突变的协同效应发挥的抗癌作用","authors":"Ai-Qiu Liao, Juan Wen, Jing-Chen Wei, Bing-Bing Xu, Nan Jin, Hong-Yu Lin, Xiu-Ying Qin","doi":"10.1016/j.ejmech.2024.116954","DOIUrl":null,"url":null,"abstract":"Three novel copper(II)-based complexes <strong>Cu-1</strong>, <strong>Cu-2</strong>, and <strong>Cu-3</strong> containing sulfamethoxazole or sulfamethazine ligand were obtained, and their single structures were characterized. Both <strong>Cu-1</strong> and <strong>Cu-3</strong> show a broad spectrum of cytotoxicity than <strong>Cu-2</strong>, and <strong>Cu-1</strong> is more cytotoxic than <strong>Cu-3</strong>. What's interesting is that <strong>Cu-1</strong> can exhibit obvious inhibitory effect on the growth of human triple-negative breast cancer in vivo and vitro through anti-proliferative, anti-angiogenic, anti-inflammatory, pro-apoptotic and cuproptotic synergistic effects. Though <strong>Cu-3</strong> shows no significant cytotoxicity against MDA-MB-231 cells, it can significantly inhibit the growth of SKOV3 cells in vitro by down-regulating the expression of some key proteins in the VEGF/VEGFR2 signaling pathway and the expression of some pro-inflammatory cytokines, and by disrupting the balance of intracellular reactive oxygen species levels.","PeriodicalId":314,"journal":{"name":"European Journal of Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Syntheses, Crystal Structures of Copper (II)-based Complexes of Sulfonamide Derivatives and Their Anticancer Effects Through the Synergistic Effect of Anti-angiogenesis, Anti-inflammation, Pro-apoptosis and Cuproptosis\",\"authors\":\"Ai-Qiu Liao, Juan Wen, Jing-Chen Wei, Bing-Bing Xu, Nan Jin, Hong-Yu Lin, Xiu-Ying Qin\",\"doi\":\"10.1016/j.ejmech.2024.116954\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Three novel copper(II)-based complexes <strong>Cu-1</strong>, <strong>Cu-2</strong>, and <strong>Cu-3</strong> containing sulfamethoxazole or sulfamethazine ligand were obtained, and their single structures were characterized. Both <strong>Cu-1</strong> and <strong>Cu-3</strong> show a broad spectrum of cytotoxicity than <strong>Cu-2</strong>, and <strong>Cu-1</strong> is more cytotoxic than <strong>Cu-3</strong>. What's interesting is that <strong>Cu-1</strong> can exhibit obvious inhibitory effect on the growth of human triple-negative breast cancer in vivo and vitro through anti-proliferative, anti-angiogenic, anti-inflammatory, pro-apoptotic and cuproptotic synergistic effects. Though <strong>Cu-3</strong> shows no significant cytotoxicity against MDA-MB-231 cells, it can significantly inhibit the growth of SKOV3 cells in vitro by down-regulating the expression of some key proteins in the VEGF/VEGFR2 signaling pathway and the expression of some pro-inflammatory cytokines, and by disrupting the balance of intracellular reactive oxygen species levels.\",\"PeriodicalId\":314,\"journal\":{\"name\":\"European Journal of Medicinal Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2024-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Medicinal Chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ejmech.2024.116954\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ejmech.2024.116954","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Syntheses, Crystal Structures of Copper (II)-based Complexes of Sulfonamide Derivatives and Their Anticancer Effects Through the Synergistic Effect of Anti-angiogenesis, Anti-inflammation, Pro-apoptosis and Cuproptosis
Three novel copper(II)-based complexes Cu-1, Cu-2, and Cu-3 containing sulfamethoxazole or sulfamethazine ligand were obtained, and their single structures were characterized. Both Cu-1 and Cu-3 show a broad spectrum of cytotoxicity than Cu-2, and Cu-1 is more cytotoxic than Cu-3. What's interesting is that Cu-1 can exhibit obvious inhibitory effect on the growth of human triple-negative breast cancer in vivo and vitro through anti-proliferative, anti-angiogenic, anti-inflammatory, pro-apoptotic and cuproptotic synergistic effects. Though Cu-3 shows no significant cytotoxicity against MDA-MB-231 cells, it can significantly inhibit the growth of SKOV3 cells in vitro by down-regulating the expression of some key proteins in the VEGF/VEGFR2 signaling pathway and the expression of some pro-inflammatory cytokines, and by disrupting the balance of intracellular reactive oxygen species levels.
期刊介绍:
The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers.
A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.