筛选噪音:扩散概率模型概览及其在生物分子中的应用》。

IF 4.7 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Biology Pub Date : 2024-10-09 DOI:10.1016/j.jmb.2024.168818
Trevor Norton, Debswapna Bhattacharya
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引用次数: 0

摘要

扩散概率模型自问世以来,已被广泛应用。特别是在生物分子结构和序列的预测与设计中使用扩散模型的研究浪潮。由于扩散模型越来越普遍,这些领域的研究人员必须了解它们。本文概述了这些模型背后的理论和研究现状。我们首先介绍了扩散模型,并讨论了将这些模型应用于生物大分子时的常见模式。然后,我们介绍了在生成和预测任务中应用这些模型所取得的重要成果。本调查旨在让读者全面了解扩散模型日益重要的作用。
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Sifting through the noise: A survey of diffusion probabilistic models and their applications to biomolecules.

Diffusion probabilistic models have made their way into a number of high-profile applications since their inception. In particular, there has been a wave of research into using diffusion models in the prediction and design of biomolecular structures and sequences. Their growing ubiquity makes it imperative for researchers in these fields to understand them. This paper serves as a general overview for the theory behind these models and the current state of research. We first introduce diffusion models and discuss common motifs used when applying them to biomolecules. We then present the significant outcomes achieved through the application of these models in generative and predictive tasks. This survey aims to provide readers with a comprehensive understanding of the increasingly critical role of diffusion models.

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来源期刊
Journal of Molecular Biology
Journal of Molecular Biology 生物-生化与分子生物学
CiteScore
11.30
自引率
1.80%
发文量
412
审稿时长
28 days
期刊介绍: Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.
期刊最新文献
Editorial Board Outside Front Cover Assembly of the human multi-tRNA synthetase complex through leucine zipper motifs. Corrigendum to “The Role of ATG9 Vesicles in Autophagosome Biogenesis” [J. Mol. Biol. 436(15) (2024) 168489] Structural studies on Mycobacterial NudC reveal a class of zinc independent NADH pyrophosphatase.
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