Jieping Sun , Jinghan Dang , Mengzhe zhang , Xiaoyu Niu , Qiuying Tao , Yimeng Kang , Longyao Ma , Bohui Mei , Yarui Wei , Weijian Wang , Shaoqiang Han , Jingliang Cheng , Yong Zhang
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引用次数: 0
摘要
吸烟是认知障碍和精神障碍的高危人群。本研究旨在探讨尼古丁使用对初级视觉网络（PVN）的影响及其与神经递质的关联。共有59名烟草使用障碍（TUD）患者和51名健康对照（HC）参加了这项研究，并接受了静息状态功能磁共振成像扫描。研究人员使用独立成分分析法探讨了网络内的功能连接性（FC）。此外，还使用 JuSpace 工具箱和 SPSS 评估了 PVN 变化与神经递质的空间相关性及其与患者临床特征的相关性。我们发现，与 HC 相比，TUD 患者 PVN 内的 FC 减少。在相关分析方面，患者 PVN 中的 FC 变化与多巴胺受体和γ-氨基丁酸受体的较高分布存在空间相关性。该研究揭示了TUD患者PVN的FC和神经递质的变化，拓展了感觉知觉和精神障碍的潜在神经机制。
Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study
Smoking puts patients at high risk for cognitive and psychiatric disorders. The aim of this study was to explore the effects of nicotine use on primary visual network (PVN) and its association with neurotransmitters. A total of 59 tobacco use disorder (TUD) patients and 51 healthy controls (HC) participated in this study and underwent resting state functional magnetic resonance imaging scans. Functional connectivity (FC) within the network was explored using independent component analysis. In addition, the spatial correlations of PVN changes with neurotransmitters and their correlations with clinical characteristics of patients were evaluated using the JuSpace toolbox and SPSS. We found reduced FC within the PVN in patients with TUD compared with HC. In terms of relevant analysis, there is a spatial correlation between FC changes in the patient's PVN and a higher distribution of dopamine receptor and gamma-aminobutyric acid receptor. This study revealed changes in the FC and neurotransmitters of the PVN in patients with TUD, expanding the potential neural mechanisms underlying sensory perception and psychiatric disorders.
期刊介绍：
The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.
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